Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models

LF Costa-Machado, E Garcia-Dominguez… - Nature …, 2023 - nature.com
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory
responses that ultimately improve mitochondrial function, a conserved anti-aging …

5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development

GSV Higa, J Francis-Oliveira, E Carlos-Lima… - Scientific Reports, 2022 - nature.com
Important functions of the prefrontal cortex (PFC) are established during early life, when
neurons exhibit enhanced synaptic plasticity and synaptogenesis. This developmental stage …