Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …

Rac1 is a member of the Rho GTPase family which plays major roles in cell mobility, polarity
and migration, as a fundamental regulator of actin cytoskeleton. Signal transduction by Rac1 …

Glioblastoma (GBM) represents a prevalent form of primary malignant tumours in the central
nervous system, but the options for effective treatment are extremely limited. Ferroptosis, as …

Background In brain tumors, the complexity of the pathophysiological processes such as
oxidative stress, cell proliferation, angiogenesis, and apoptosis have seriously challenged …

The current standard oncotherapy for glioblastoma is limited by several adverse side effects,
leading to a short-term patient survival rate paralleled by a worsening quality of life (QoL) …

Glioblastoma multiforme (GBM) is one of the most prevalent and lethal primary central
nervous system malignancies. GBM is notorious for its high rates of recurrence and therapy …

Background and aims Glioblastoma (GBM) is an aggressive primary brain cancer with no
promising curative therapies. It has been indicated that MSCs can interact with the tumour …

Background This case series describes the safety and efficacy of superselective intra-arterial
(IA) cerebral infusion of teniposide for the treatment of patients with glioma, to provide new …

Background: Developing therapeutic or functional supportive therapeutic strategies for
neurodegenerative (ND) diseases (NDDs) or tumor as glioma or glioblastoma (GBM) …

Background. The combination of temozolomide (TMZ) and paclitaxel (PTX) is the most
commonly used chemotherapy regimen for glioblastoma, but there is no specific treatment …