Background Drug-induced drug resistance in cancer has been attributed to diverse
biological mechanisms at the individual cell or cell population scale, relying on …

The 'cancer stem cell'hypothesis has pointed to a specific target for new cancer therapies.
The hypothesis is based on the observation that only the 'cancer stem cell'among the other …

Background A thorough understanding of the ecological and evolutionary mechanisms that
drive the phenotypic evolution of neoplastic cells is a timely and key challenge for the cancer …

Early observations showed a lack of growth control and terminal differentiation with a lack of
gap junctional intercellular communication (GJIC). Subsequent observations showed that …

This article is a proceeding survey (deepening a talk given by the first author at the BioMath
2019 International Conference on Mathematical Models and Methods, held in Będlewo …

Coherent multicellular organisms are not only cohesive from a spatial and anatomical point
of view but also coherent from the phenotypic and cell-functional point of view of …

To find a scientifically based method for evaluating mechanistic data related to risks to
human beings, a new protocol for identifying, organizing, and summarizing mechanistic data …

This “Commentary” examines an important clinical observation that right-sided colorectal
cancers appear less treatable than the left-sided cancers. The concepts of (a) the …

It has been proposed that many human cancers are generated by intrinsic mechanisms that
produce “Bad Luck” mutations by the proliferation of organ-specific adult stem cells. There …

Gap junctions (GJs) play a major role in the control of cell structure, function, and
metabolism. However, the molecular mechanisms involved are still poorly understood …