An evolutionary perspective on cancer, with applications to anticancer drug resistance modelling and perspectives in therapeutic control

J Clairambault - Journal of Mathematical Study, 2019 - inria.hal.science
The question of a mathematical representation and theoretical overcoming by op-timised
therapeutic strategies of drug-induced drug resistance in cancer cell populations is tackled …

The long evolutionary journey of cancer from ancestor to modern humans

G Carruba, JE Trosko - Critical Reviews™ in Oncogenesis, 2017 - dl.begellhouse.com
In this article, we review various key issues in cancer development and progression that
have important implications for both cancer prevention and treatment:(1) evolutionary …

A historical perspective for the development of mechanistic-based 3d models of toxicology using human adult stem cells

JE Trosko - Toxicological Sciences, 2018 - academic.oup.com
Given the classical approach to use (1) animals as sentinels for human toxicities and their
related pathologies, as well as for drug discovery, and (2) epidemiology to identify potential …

Physiologically structured cell population dynamic models with applications to combined drug delivery optimisation in oncology

J Clairambault, O Fercoq - Mathematical Modelling of Natural …, 2016 - mmnp-journal.org
In this paper, we introduce a model for drug delivery optimisation in a chronotherapeutics
framework. We present a pharmacokinetics and pharmacodynamics model for oxaliplatin …

[HTML][HTML] Mechanisms of Epigenetic Toxicity in the Pathogenesis of Cancer for" Precision Medicine"

JE Trosko - Journal of Cancer Treatment and …, 2018 - cancertreatmentjournal.com
While the concept of “precision medicine” is not new, sophisticated technologies have led to
a view that the data generated will provide individuals, physicians and public policy-makers …

[PDF][PDF] Evolving Concepts of Food Safety: The Need for Understanding Mechanisms of Food Toxicology for Public Policy

JE Trosko - crisis, 2018 - opastpublishers.com
Nutrition and diet, which are fundamental to human development and health, in the context
of food safety, can be major determinants in the prevention and contributor to both acute and …

[PDF][PDF] A survey of adaptive cell population dynamics models of emergence of drug resistance in cancer, and open questions about evolution and cancer, Biomath 8 …

J Clairambault, C Pouchol - 2015 - pdfs.semanticscholar.org
This article is a proceeding sur-vey (deepening a talk given by the first author at the BioMath
2019 International Conference on Mathematical Models and Methods, held in Będlewo …