Ischemia is a multifactorial pathology characterized by different events evolving in the time.
After ischemia a primary damage due to the early massive increase of extracellular …

The extracellular concentration of adenosine in the brain increases dramatically during
ischemia. Adenosine A2A receptor is expressed in neurons and glial cells and in …

Bone is continually being remodeled and defects in the processes involved lead to bone
diseases. Many regulatory factors are known to influence remodeling but other mechanisms …

Ischemic stroke is a complex pathology characterized by a sequence of events that evolve
over time and space. It is the second leading cause of death and the main cause of adult …

With the ever-increasing consumption of pharmaceutical compounds, their presence in the
environment is now an undisputable reality. The majority of these compounds are released …

Following a molecular simplification approach, we have identified the 2-phenylphthalazin-1
(2 H)-one (PHTZ) ring system as a new decorable core skeleton for the design of novel hA3 …

By taking advantage of some recently synthesized compounds that are able to block ecto-
ATPase activity, we demonstrated that adenosine triphosphate (ATP) in the hippocampus …

Investigations into the role of the adenosine A2b receptor have been enigmatic due to the
lack of good selective high affinity agonists and antagonists. Over the last few years several …

The paper describes a new class of human (h) A3 adenosine receptor antagonists, the 2-
arylpyrido [2, 3-e]-1, 2, 4-triazolo [4, 3-a] pyrazin-1-one derivatives (PTP), either 4-oxo (1− 6 …

On the basis of our previously reported 2-arylpyrazolo [4, 3-d] pyrimidin-7-ones, a set of 2-
arylpyrazolo [4, 3-d] pyrimidin-7-amines were designed as new human (h) A3 adenosine …