Mitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases,
including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and …

Axon degeneration is a prominent early feature of most neurodegenerative disorders and
can also be induced directly by nerve injury in a process known as Wallerian degeneration …

It is generally accepted that healthy cells degrade their own mitochondria. Here, we report
that retinal ganglion cell axons of WT mice shed mitochondria at the optic nerve head …

Traumatic axonal injury (TAI) is an important pathoanatomical subgroup of traumatic brain
injury (TBI) and a major driver of mortality and functional impairment. Experimental models …

The past 20 years have resulted in unprecedented progress in understanding brain energy
metabolism and its role in health and disease. In this review, which was initiated at the 14th …

Mitophagy is an essential process for mitochondrial quality control and turnover. It is
activated by two distinct pathways, one dependent on ubiquitin and the other dependent on …

Mitochondria are essential organelles for neuronal growth, survival, and function. Neurons
use specialized mechanisms to drive mitochondria transport and to anchor them in axons …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Alzheimer's disease (AD) is characterized by brain deposition of amyloid plaques and tau
neurofibrillary tangles along with steady cognitive decline. Synaptic damage, an early …

Accumulation of dysfunctional mitochondria is one of the hallmarks in Alzheimer's disease
(AD). Mitophagy, a selective autophagy for eliminating damaged mitochondria, constitutes a …