Mitochondria-associated membranes: composition, molecular mechanisms, and physiopathological implications
Significance: In all cells, the endoplasmic reticulum (ER) and mitochondria are physically
connected to form junctions termed mitochondria-associated membranes (MAMs). This …
connected to form junctions termed mitochondria-associated membranes (MAMs). This …
Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics
J Janikiewicz, J Szymański, D Malinska… - Cell death & …, 2018 - nature.com
Sites of close contact between mitochondria and the endoplasmic reticulum (ER) are known
as mitochondria-associated membranes (MAM) or mitochondria-ER contacts (MERCs), and …
as mitochondria-associated membranes (MAM) or mitochondria-ER contacts (MERCs), and …
Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells
Insulin-like growth factor II (IGF-II) is a peptide growth factor that is homologous to both
insulin-like growth factor I (IGF-I) and insulin and plays an important role in embryonic …
insulin-like growth factor I (IGF-I) and insulin and plays an important role in embryonic …
The mitochondria–endoplasmic reticulum contacts and their critical role in aging and age-associated diseases
The recent discovery of interconnections between the endoplasmic reticulum (ER)
membrane and those of almost all the cell compartments is providing novel perspectives for …
membrane and those of almost all the cell compartments is providing novel perspectives for …
The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification.
N Prenzel, OM Fischer, S Streit, S Hart… - Endocrine-related …, 2001 - erc.bioscientifica.com
Homeostasis of multicellular organisms is critically dependent on the correct interpretation of
the plethora of signals which cells are exposed to during their lifespan. Various soluble …
the plethora of signals which cells are exposed to during their lifespan. Various soluble …
Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?
Abstract Insulin and Insulin Growth Factor-1 (IGF-1) play a major role in body homeostasis
and glucose regulation. They also have paracrine/autocrine functions in the brain. The …
and glucose regulation. They also have paracrine/autocrine functions in the brain. The …
Epidermal growth factor receptors: critical mediators of multiple receptor pathways
PO Hackel, E Zwick, N Prenzel, A Ullrich - Current opinion in cell biology, 1999 - Elsevier
Recently, the receptor for epidermal growth factor (EGF) was identified as a downstream
element in different signaling pathways. This expanded its classical function as a receptor …
element in different signaling pathways. This expanded its classical function as a receptor …
Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor‐dependent, transcription‐independent …
JD Croxtall, Q Choudhury… - British journal of …, 2000 - Wiley Online Library
Recruitment to activated tyrosine kinase growth factor receptors of Grb2 and p21ras leads to
downstream activation of the kinases Raf, MAPK/Erk kinase (Mek) and, subsequently …
downstream activation of the kinases Raf, MAPK/Erk kinase (Mek) and, subsequently …
Signal transduction via the growth hormone receptor
Rapid progress has been made recently in the definition of growth hormone (GH) receptor
signal transduction pathways. It is now apparent that many cytokines, including GH, share …
signal transduction pathways. It is now apparent that many cytokines, including GH, share …
Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances
K Siddle - Frontiers in endocrinology, 2012 - frontiersin.org
Insulin and insulin-like growth factor (IGF) receptors utilize common phosphoinositide 3-
kinase/Akt and Ras/extracellular signal-regulated kinase signaling pathways to mediate a …
kinase/Akt and Ras/extracellular signal-regulated kinase signaling pathways to mediate a …