Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages
in some patients, immunoparalysis may be encountered, which is associated with a poor …

Sirtuins (SIRT), first discovered in yeast as NAD+ dependent epigenetic and metabolic
regulators, have comparable activities in human physiology and disease. Mounting …

Sepsis, a life threating syndrome characterized by organ failure after infection, is the most
common cause of death in hospitalized patients. The treatment of sepsis is generally …

Sepsis is known since the time (470 BC) of great Greek physician, Hippocrates.
Advancement in modern medicine and establishment of separate branches of medical …

Critically ill, severely injured and high-risk surgical patients are vulnerable to secondary
infections during hospitalization and after hospital discharge. Studies show that the …

Sepsis develops when an infection surpasses local tissue containment. A series of
dysregulated physiological responses are generated, leading to organ dysfunction and a …

Objectives: Recent evidence from the fields of microbiology and immunology, as well as a
small number of human sepsis studies, suggest that epigenetic regulation may play a central …

A model of the development and progression of chronic fatigue syndrome (myalgic
encephalomyelitis), the aetiology of which is currently unknown, is put forward, starting with …