Is atrial fibrillation an inflammatory disorder?

CJ Boos, RA Anderson, GYH Lip - European heart journal, 2006 - academic.oup.com
There is mounting evidence to support the influence of inflammation in the pathogenesis of
atrial fibrillation (AF). Indeed, AF is associated with increased levels of known inflammatory …

Role of inflammation in initiation and perpetuation of atrial fibrillation: a systematic review of the published data

TT Issac, H Dokainish, NM Lakkis - Journal of the American College of …, 2007 - jacc.org
Role of Inflammation in Initiation and Perpetuation of Atrial Fibrillation: A Systematic Review
of the Published Data Tim T. Issac, Hisham Dokainish, Nasser M. Lakkis Atrial fibrillation …

Angiotensin converting enzyme 2 activity and human atrial fibrillation: increased plasma angiotensin converting enzyme 2 activity is associated with atrial fibrillation …

TE Walters, JM Kalman, SK Patel, M Mearns… - Ep …, 2017 - academic.oup.com
Aim Angiotensin converting enzyme 2 (ACE2) is an integral membrane protein whose main
action is to degrade angiotensin II. Plasma ACE2 activity is increased in various …

Structural and functional remodeling of the left atrium: clinical and therapeutic implications for atrial fibrillation

G Casaclang-Verzosa, BJ Gersh, TSM Tsang - Journal of the American …, 2008 - jacc.org
Left atrial (LA) structural and functional remodeling reflects a spectrum of pathophysiological
changes that have occurred in response to specific stressors. These changes include …

Valsartan for prevention of recurrent atrial fibrillation

GISSI-AF Investigators - New England Journal of Medicine, 2009 - Mass Medical Soc
Background Atrial fibrillation is the most common cardiac arrhythmia, and no current therapy
is ideal for control of this condition. Experimental studies suggest that angiotensin II …

Prevention of Pathological Atrial Remodeling and Atrial Fibrillation: JACC State-of-the-Art Review

YC Chen, A Voskoboinik, AL Gerche… - Journal of the American …, 2021 - jacc.org
Atrial enlargement in response to pathological stimuli (eg, hypertension, mitral valve
disease) and physiological stimuli (exercise, pregnancy) can be comparable in magnitude …

Valsartan reduces the incidence of atrial fibrillation in patients with heart failure: results from the Valsartan Heart Failure Trial (Val-HeFT)

AP Maggioni, R Latini, PE Carson, SN Singh… - American heart …, 2005 - Elsevier
BACKGROUND: Atrial fibrillation (AF) in heart failure (HF) is generally considered a
negative prognostic factor. Recent studies indicate that the incidence of AF might be …

Atrial fibrosis and the mechanisms of atrial fibrillation

TH Everett IV, JE Olgin - Heart rhythm, 2007 - Elsevier
Atrial fibrillation (AF) is commonly associated with congestive heart failure (CHF), and CHF
has been shown to be associated with atrial structural remodeling resulting in fibrosis. Atrial …

Left atrial disease and left atrial reverse remodelling across different stages of heart failure development and progression: a new target for prevention and treatment

RM Inciardi, A Bonelli… - European Journal of …, 2022 - Wiley Online Library
The left atrium is a dynamic chamber with peculiar characteristics. Stressors and disease
mechanisms may deeply modify its structure and function, leading to left atrial remodelling …

Prevention of atrial fibrillation in patients with symptomatic chronic heart failure by candesartan in the Candesartan in Heart failure: Assessment of Reduction in …

A Ducharme, K Swedberg, MA Pfeffer… - American heart …, 2006 - Elsevier
BACKGROUND: Atrial fibrillation (AF) is frequent in patients with chronic heart failure (CHF).
Experimental and small patient studies have demonstrated that blocking the renin …