Regulation of hematopoietic and leukemic stem cells by the immune system
C Riether, CM Schürch, AF Ochsenbein - Cell death & differentiation, 2015 - nature.com
Hematopoietic stem cells (HSCs) are rare, multipotent cells that generate via progenitor and
precursor cells of all blood lineages. Similar to normal hematopoiesis, leukemia is also …
precursor cells of all blood lineages. Similar to normal hematopoiesis, leukemia is also …
Awakening dormant haematopoietic stem cells
Haematopoietic stem cells (HSCs) in mouse bone marrow are located in specialized niches
as single cells. During homeostasis, signals from this environment keep some HSCs …
as single cells. During homeostasis, signals from this environment keep some HSCs …
IFNα activates dormant haematopoietic stem cells in vivo
MAG Essers, S Offner, WE Blanco-Bose, Z Waibler… - Nature, 2009 - nature.com
Maintenance of the blood system is dependent on dormant haematopoietic stem cells
(HSCs) with long-term self-renewal capacity. After injury these cells are induced to …
(HSCs) with long-term self-renewal capacity. After injury these cells are induced to …
Opportunities, barriers, and a strategy for overcoming translational challenges to therapeutic nucleic acid nanotechnology
606Recent clinical successes using therapeutic nucleic acids (TNAs) have accelerated the
transition of nucleic acid nanotechnology toward therapeutic applications. Significant …
transition of nucleic acid nanotechnology toward therapeutic applications. Significant …
Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population
LRV Antonelli, AG Rothfuchs… - The Journal of …, 2010 - Am Soc Clin Investig
Type I IFN has been demonstrated to have major regulatory effects on the outcome of
bacterial infections. To assess the effects of exogenously induced type I IFN on the outcome …
bacterial infections. To assess the effects of exogenously induced type I IFN on the outcome …
Relapse after allogeneic stem cell transplantation
AJ Barrett, M Battiwalla - Expert review of hematology, 2010 - Taylor & Francis
Since allogeneic stem cell transplantation (SCT) represents an intensive curative treatment
for high-risk malignancies, its failure to prevent relapse leaves few options for successful …
for high-risk malignancies, its failure to prevent relapse leaves few options for successful …
Inflammatory signaling pathways in preleukemic and leukemic stem cells
S Hemmati, T Haque, K Gritsman - Frontiers in oncology, 2017 - frontiersin.org
Hematopoietic stem cells (HSCs) are a rare subset of bone marrow cells that usually exist in
a quiescent state, only entering the cell cycle to replenish the blood compartment, thereby …
a quiescent state, only entering the cell cycle to replenish the blood compartment, thereby …
Perspectives on interferon-alpha in the treatment of polycythemia vera and related myeloproliferative neoplasms: minimal residual disease and cure?
HC Hasselbalch, MO Holmström - Seminars in Immunopathology, 2019 - Springer
The first clinical trials of the safety and efficacy of interferon-alpha2 (IFN-alpha2) were
performed about 30 years ago. Since then, several single-arm studies have convincingly …
performed about 30 years ago. Since then, several single-arm studies have convincingly …
Use of human peripheral blood mononuclear cells to define immunological properties of nucleic acid nanoparticles
MA Dobrovolskaia, KA Afonin - Therapeutic RNA Nanotechnology, 2021 - taylorfrancis.com
This protocol assesses proinflammatory properties of nucleic acid nanoparticles (NANPs)
using a validated preclinical model, peripheral blood mononuclear cells (PBMCs), that is …
using a validated preclinical model, peripheral blood mononuclear cells (PBMCs), that is …
Interferon-α in acute myeloid leukemia: an old drug revisited
S Anguille, E Lion, Y Willemen, VFI Van Tendeloo… - Leukemia, 2011 - nature.com
Abstract Interferon-α (IFN-α), a type I IFN, is a well-known antitumoral agent. The
investigation of its clinical properties in acute myeloid leukemia (AML) has been prompted …
investigation of its clinical properties in acute myeloid leukemia (AML) has been prompted …