Hematopoietic stem cells (HSCs) are rare, multipotent cells that generate via progenitor and
precursor cells of all blood lineages. Similar to normal hematopoiesis, leukemia is also …

Haematopoietic stem cells (HSCs) in mouse bone marrow are located in specialized niches
as single cells. During homeostasis, signals from this environment keep some HSCs …

Maintenance of the blood system is dependent on dormant haematopoietic stem cells
(HSCs) with long-term self-renewal capacity. After injury these cells are induced to …

606Recent clinical successes using therapeutic nucleic acids (TNAs) have accelerated the
transition of nucleic acid nanotechnology toward therapeutic applications. Significant …

Type I IFN has been demonstrated to have major regulatory effects on the outcome of
bacterial infections. To assess the effects of exogenously induced type I IFN on the outcome …

Since allogeneic stem cell transplantation (SCT) represents an intensive curative treatment
for high-risk malignancies, its failure to prevent relapse leaves few options for successful …

Hematopoietic stem cells (HSCs) are a rare subset of bone marrow cells that usually exist in
a quiescent state, only entering the cell cycle to replenish the blood compartment, thereby …

The first clinical trials of the safety and efficacy of interferon-alpha2 (IFN-alpha2) were
performed about 30 years ago. Since then, several single-arm studies have convincingly …

This protocol assesses proinflammatory properties of nucleic acid nanoparticles (NANPs)
using a validated preclinical model, peripheral blood mononuclear cells (PBMCs), that is …

Abstract Interferon-α (IFN-α), a type I IFN, is a well-known antitumoral agent. The
investigation of its clinical properties in acute myeloid leukemia (AML) has been prompted …