For decades, immunologists have studied the role of circulating immune cells in host
protection, with a more recent appreciation of immune cells resident within the tissue …

Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

The delivery of medical agents to a specific diseased tissue or cell is critical for diagnosing
and treating patients. Nanomaterials are promising vehicles to transport agents that include …

An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …

Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …

Tissue adhesives can form appreciable adhesion with tissues and have found clinical use in
a variety of medical settings such as wound closure, surgical sealants, regenerative …

Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …

The infrapatellar fat pad (IPFP) and synovium play essential roles in maintaining knee joint
homeostasis and in the progression of osteoarthritis (OA). The cellular and transcriptional …

We report that cardiac fibroblasts (CFs) and mesenchymal progenitors are more hypoxic
than other cardiac interstitial populations, express more hypoxia-inducible factor 1α (HIF …