THE PAST decade has witnessed an upsurge in our understanding of the hypothalamic
regulation of appetite. Expression of appetite or the motivational drive toward an energy …

In recent years, studies have advocated neuropeptide systems as modulators for the
behavioral states found in mood disorders such as depression and anxiety disorders …

Dr. Jacqueline N. Crawley, author of the First and Second Editions of What's Wrong with My
Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, continues to field calls …

Peptide neurotransmitters and peptide hormones, collectively known as neuropeptides, are
required for cell-cell communication in neurotransmission and for regulation of endocrine …

Galanin is a widely distributed neuropeptide with a variety of physiological functions. Three
galanin receptor subtypes, GALR1, GALR2, and GALR3, have been reported. We isolated a …

The diverse physiological functions exerted by the neuropeptide galanin may be regulated
by multiple G protein-coupled receptor subtypes and intracellular signaling pathways. Three …

Galanin, a 29–30 amino acid neuropeptide, is found in the central and peripheral nervous
systems and displays several important physiological activities. The actions are believed to …

The neuropeptide galanin mediates its effects through the receptor subtypes Gal1, Gal2, and
Gal3 and has been implicated in anxiety-and depression-related behaviors. Nevertheless …

Scientific and commercial pharmacological interest in the role of galanin and galanin
receptors in the regulation of food intake, energy balance, and obesity has waned recently …

Galanin inhibits food consumption in satiated rats. Discovered relatively recently, galanin is
a 29-amino-acid neuropeptide, not homologous with any other known peptide. Three G …