Factor V Leiden is a genetic disorder characterized by a poor anticoagulant response to
activated Protein C and an increased risk for venous thromboembolism. Deep venous …

The annual incidence of venous thrombosis, one of the leading causes of mortality and
morbidity, increases from 1 per 100,000 during childhood to 1 per 100 in old age. 1 In this …

Venous thrombosis occurs in about 1 per 1,000 individuals per year. 1, 2 It usually affects
the deep veins of the leg, but may occur in other sites, such as the upper extremities …

Thrombophilia can be defined as a predisposition to form clots inappropriately. Thrombotic
events during infancy and childhood are increasingly recognized as a significant source of …

The development of thrombotic disorders in humans is one of the most common causes of
morbidity and mortality in the Western world. Thrombotic disease can be classified in broad …

Venous thrombosis, whose main clinical presentations include deep vein thrombosis and
pulmonary embolism, represents a major health problem worldwide. Numerous conditions …

Venous thromboembolism (VTE) has important heritable components. In the past 20 years,
knowledge in this field has greatly increased with the identification of a number of gene …

Activated protein C (APC) resistance caused by the factor V Leiden mutation is associated
with an increased risk of venous thrombosis. We investigated whether a reduced response …

Background The factor Va molecule is generated by cleavage of its precursor factor V. It
contributes to the blood clotting reaction by binding with factor Xa on a membrane surface to …

The generation of thrombin by the prothrombinase complex constitutes an essential step in
hemostasis, with thrombin being crucial for the amplification of blood coagulation, fibrin …