TRPV4: A trigger of pathological RhoA activation in neurological disease
Transient receptor potential vanilloid 4 (TRPV4), a member of the TRP superfamily, is a
broadly expressed, cell surface‐localized cation channel that is activated by a variety of …
broadly expressed, cell surface‐localized cation channel that is activated by a variety of …
Experimental treatments to attenuate blood spinal cord barrier rupture in rats with traumatic spinal cord injury: A meta-analysis and systematic review
L Deng, JQ Lv, L Sun - Frontiers in Pharmacology, 2022 - frontiersin.org
Background: Traumatic spinal cord injury (t-SCI) is a severe injury that has a devastating
impact on neurological function. Blood spinal cord barrier (BSCB) destruction following SCI …
impact on neurological function. Blood spinal cord barrier (BSCB) destruction following SCI …
[HTML][HTML] SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc
T Jiang, T Qin, P Gao, Z Tao, X Wang, M Wu, J Gu… - Redox Biology, 2023 - Elsevier
Disruption of the blood-spinal cord barrier (BSCB) leads to inflammatory cell infiltration and
neural cell death, thus, contributing to poor functional recovery after spinal cord injury (SCI) …
neural cell death, thus, contributing to poor functional recovery after spinal cord injury (SCI) …
Biodegradable bilayer hydrogel membranes loaded with bazedoxifene attenuate blood–spinal cord barrier disruption via the NF-κB pathway after acute spinal cord …
W Xin, Z Baokun, C Zhiheng, S Qiang, Y Erzhu… - Acta Biomaterialia, 2023 - Elsevier
After spinal cord injury (SCI), blood–spinal cord barrier (BSCB) disruption and hemorrhage
lead to blood cell infiltration and progressive secondary injuries. Therefore, early restoration …
lead to blood cell infiltration and progressive secondary injuries. Therefore, early restoration …
Pharmacological interventions targeting the microcirculation following traumatic spinal cord injury
R Wang, J Bai - Neural Regeneration Research, 2024 - journals.lww.com
Traumatic spinal cord injury is a devastating disorder characterized by sensory, motor, and
autonomic dysfunction that severely compromises an individual's ability to perform activities …
autonomic dysfunction that severely compromises an individual's ability to perform activities …
Teriparatide: an innovative and promising strategy for protecting the blood-spinal cord barrier following spinal cord injury
M Xiong, Y Feng, C Luo, J Guo, J Zeng… - Frontiers in …, 2024 - frontiersin.org
The blood-spinal cord barrier (BSCB) is disrupted within minutes of spinal cord injury,
leading to increased permeability and secondary spinal cord injury, resulting in more severe …
leading to increased permeability and secondary spinal cord injury, resulting in more severe …
Therapeutic Perspectives on ROCK Inhibition for Cerebral Cavernous Malformations
TL Montagnoli, DR de Oliveira, CAM Fraga - Kinases and Phosphatases, 2023 - mdpi.com
Cerebral cavernous malformations (CCM) are developmental venous dysplasias which
present as abnormally dilated blood vessels occurring mainly in the brain. Alterations in …
present as abnormally dilated blood vessels occurring mainly in the brain. Alterations in …
创伤性脊髓损伤微循环中的靶向药物治疗
R Wang, J Bai - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
创伤性脊髓损伤主要表现为感觉, 运动, 自主神经功能障碍, 严重影响日常生活能力.
这些不良结果与脊髓损伤机制复杂, 中枢神经元的再生能力有限以及创伤性损伤形成的抑制环境 …
这些不良结果与脊髓损伤机制复杂, 中枢神经元的再生能力有限以及创伤性损伤形成的抑制环境 …