Inside PD-1/PD-L1, 2 with their inhibitors
N Boisgerault, P Bertrand - European Journal of Medicinal Chemistry, 2023 - Elsevier
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Drug repurposing to enhance antitumor response to PD-1/PD-L1 immune checkpoint inhibitors
X Thuru, R Magnez, H El-Bouazzati, G Vergoten… - Cancers, 2022 - mdpi.com
Simple Summary Novel pharmacological approaches are needed to improve treatments of
advanced cancers, despite the considerable benefit of immunotherapy. New drugs are …
advanced cancers, despite the considerable benefit of immunotherapy. New drugs are …
Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells
SF Mehrabi, S Elmi, J Nylandsted - Frontiers in Oncology, 2023 - frontiersin.org
The limitations of current cancer therapies, including the increasing prevalence of multidrug
resistance, underscore the urgency for more effective treatments. One promising avenue lies …
resistance, underscore the urgency for more effective treatments. One promising avenue lies …
The emerging role of noncoding RNAs in the EGFR signaling pathway in lung cancer
Noncoding ribonucleic acids (ncRNAs) have surfaced as essential orchestrators within the
intricate system of neoplastic biology. Specifically, the epidermal growth factor receptor …
intricate system of neoplastic biology. Specifically, the epidermal growth factor receptor …
BMC3PM: bioinformatics multidrug combination protocol for personalized precision medicine and its application in cancer treatment
M Mokhtari, S Khoshbakht, ME Akbari… - BMC Medical …, 2023 - Springer
Background In recent years, drug screening has been one of the most significant challenges
in the field of personalized medicine, particularly in cancer treatment. However, several new …
in the field of personalized medicine, particularly in cancer treatment. However, several new …
[HTML][HTML] Rupatadine inhibits colorectal cancer cell proliferation through the PIP5K1A/Akt/CDK2 pathway
L Jiang, Z Zhang, Z Luo, L Li, S Yuan, M Cui… - Biomedicine & …, 2024 - Elsevier
Abstract Background Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (PIP5K1A)
acts upstream of the Akt regulatory pathway and is abnormally expressed in many types of …
acts upstream of the Akt regulatory pathway and is abnormally expressed in many types of …
Beyond Psychotropic: Potential Repurposing of Fluoxetine toward Cancer Therapy
SF Kadasah, AMS Alqahtani, A Alkhammash… - International Journal of …, 2024 - mdpi.com
Drug repurposing, rebranding an existing drug for a new therapeutic indication, is deemed a
beneficial approach for a quick and cost-effective drug discovery process by skipping …
beneficial approach for a quick and cost-effective drug discovery process by skipping …
Miglitol, an oral antidiabetic drug, downregulates melanogenesis in b16f10 melanoma cells through the pka, mapk, and gsk3β/β-catenin signaling pathways
HM Kim, CG Hyun - Molecules, 2022 - mdpi.com
Hyperpigmentation is a common condition that causes darker spots or patches on the skin,
which often look brown, black, gray, red, or pink. This results in unresolved psychological …
which often look brown, black, gray, red, or pink. This results in unresolved psychological …
Structure–Activity Relationships and Therapeutic Applications of Retinoids in View of Potential Benefits from Drug Repurposing Process
Vitamin A, an essential micronutrient, is integral to various biological processes crucial for
organismal development and maintenance. Dietary sources of vitamin A encompass …
organismal development and maintenance. Dietary sources of vitamin A encompass …
Utilizing topological indices in QSPR modeling to identify non-cancer medications with potential anti-cancer properties: a promising strategy for drug repurposing
S Yousaf, K Shahzadi - Frontiers in Chemistry, 2024 - frontiersin.org
The exploration of non-cancer medications with potential anti-cancer activity offers a
promising avenue for drug repurposing, accelerating the development of new oncological …
promising avenue for drug repurposing, accelerating the development of new oncological …