Inside PD-1/PD-L1, 2 with their inhibitors

N Boisgerault, P Bertrand - European Journal of Medicinal Chemistry, 2023 - Elsevier
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Drug repurposing to enhance antitumor response to PD-1/PD-L1 immune checkpoint inhibitors

X Thuru, R Magnez, H El-Bouazzati, G Vergoten… - Cancers, 2022 - mdpi.com
Simple Summary Novel pharmacological approaches are needed to improve treatments of
advanced cancers, despite the considerable benefit of immunotherapy. New drugs are …

Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells

SF Mehrabi, S Elmi, J Nylandsted - Frontiers in Oncology, 2023 - frontiersin.org
The limitations of current cancer therapies, including the increasing prevalence of multidrug
resistance, underscore the urgency for more effective treatments. One promising avenue lies …

The emerging role of noncoding RNAs in the EGFR signaling pathway in lung cancer

S Mohan, MA Hakami, HG Dailah, A Khalid… - … -Research and Practice, 2023 - Elsevier
Noncoding ribonucleic acids (ncRNAs) have surfaced as essential orchestrators within the
intricate system of neoplastic biology. Specifically, the epidermal growth factor receptor …

BMC3PM: bioinformatics multidrug combination protocol for personalized precision medicine and its application in cancer treatment

M Mokhtari, S Khoshbakht, ME Akbari… - BMC Medical …, 2023 - Springer
Background In recent years, drug screening has been one of the most significant challenges
in the field of personalized medicine, particularly in cancer treatment. However, several new …

[HTML][HTML] Rupatadine inhibits colorectal cancer cell proliferation through the PIP5K1A/Akt/CDK2 pathway

L Jiang, Z Zhang, Z Luo, L Li, S Yuan, M Cui… - Biomedicine & …, 2024 - Elsevier
Abstract Background Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (PIP5K1A)
acts upstream of the Akt regulatory pathway and is abnormally expressed in many types of …

Beyond Psychotropic: Potential Repurposing of Fluoxetine toward Cancer Therapy

SF Kadasah, AMS Alqahtani, A Alkhammash… - International Journal of …, 2024 - mdpi.com
Drug repurposing, rebranding an existing drug for a new therapeutic indication, is deemed a
beneficial approach for a quick and cost-effective drug discovery process by skipping …

Miglitol, an oral antidiabetic drug, downregulates melanogenesis in b16f10 melanoma cells through the pka, mapk, and gsk3β/β-catenin signaling pathways

HM Kim, CG Hyun - Molecules, 2022 - mdpi.com
Hyperpigmentation is a common condition that causes darker spots or patches on the skin,
which often look brown, black, gray, red, or pink. This results in unresolved psychological …

Structure–Activity Relationships and Therapeutic Applications of Retinoids in View of Potential Benefits from Drug Repurposing Process

P Kawczak, I Feszak, P Brzeziński, T Bączek - Biomedicines, 2024 - mdpi.com
Vitamin A, an essential micronutrient, is integral to various biological processes crucial for
organismal development and maintenance. Dietary sources of vitamin A encompass …

Utilizing topological indices in QSPR modeling to identify non-cancer medications with potential anti-cancer properties: a promising strategy for drug repurposing

S Yousaf, K Shahzadi - Frontiers in Chemistry, 2024 - frontiersin.org
The exploration of non-cancer medications with potential anti-cancer activity offers a
promising avenue for drug repurposing, accelerating the development of new oncological …