Ferroptosis: a double-edged sword mediating immune tolerance of cancer

Q Dang, Z Sun, Y Wang, L Wang, Z Liu, X Han - Cell death & disease, 2022 - nature.com
The term ferroptosis was put forward in 2012 and has been researched exponentially over
the past few years. Ferroptosis is an unconventional pattern of iron-dependent programmed …

Reprogramming tumor-associated macrophages as a unique approach to target tumor immunotherapy

SU Khan, MU Khan, M Azhar Ud Din, IM Khan… - Frontiers in …, 2023 - frontiersin.org
In the last ten years, it has become increasingly clear that tumor-infiltrating myeloid cells
drive not just carcinogenesis via cancer-related inflammatory processes, but also tumor …

Ferroptosis Driver SOCS1 and Suppressor FTH1 Independently Correlate With M1 and M2 Macrophage Infiltration in Head and Neck Squamous Cell Carcinoma

ZW Hu, YH Wen, RQ Ma, L Chen, XL Zeng… - Frontiers in Cell and …, 2021 - frontiersin.org
Objective To investigate the role of ferroptosis, an iron-dependent form of non-apoptotic cell
death, in the head and neck squamous cell carcinoma (HNSCC) immune microenvironment …

Iron-deficiency in atopic diseases: innate immune priming by allergens and siderophores

F Roth-Walter - Frontiers in Allergy, 2022 - frontiersin.org
Although iron is one of the most abundant elements on earth, about a third of the world's
population are affected by iron deficiency. Main drivers of iron deficiency are beside the …

Ferroptosis: Promising approach for cancer and cancer immunotherapy

S Zheng, XY Guan - Cancer Letters, 2023 - Elsevier
Ferroptosis is the cell death induced by ferrous ions and lipid peroxidation accumulation in
tumor cells. Targeting ferroptosis, which is regulated by various metabolic and immune …

Kidney single-cell transcriptome profile reveals distinct response of proximal tubule cells to SGLT2i and ARB treatment in diabetic mice

J Wu, Z Sun, S Yang, J Fu, Y Fan, N Wang, J Hu, L Ma… - Molecular Therapy, 2022 - cell.com
Angiotensin receptor blockers (ARBs) and sodium-glucose cotransporter 2 inhibitors
(SGLT2i) have been used as the standard therapy for patients with diabetic kidney disease …

Ferroptosis: Emerging mechanisms, biological function, and therapeutic potential in cancer and inflammation

X Jin, J Tang, X Qiu, X Nie, S Ou, G Wu, R Zhang… - Cell Death …, 2024 - nature.com
Ferroptosis represents a distinct form of programmed cell death triggered by excessive iron
accumulation and lipid peroxidation-induced damage. This mode of cell death differentiates …

[HTML][HTML] Inhibitory effects of temozolomide on glioma cells is sensitized by RSL3-induced ferroptosis but negatively correlated with expression of ferritin heavy chain 1 …

FC Yang, C Wang, J Zhu, QJ Gai, M Mao, J He… - Laboratory …, 2022 - Elsevier
Invasive growth of glioblastoma makes residual tumor unremovable by surgery and leads to
disease relapse. Temozolomide is widely used first-line chemotherapy drug to treat glioma …

Proteomics of adjacent-to-tumor samples uncovers clinically relevant biological events in hepatocellular carcinoma

H Zhu, Y Lin, D Lu, S Wang, Y Liu, L Dong… - National science …, 2023 - academic.oup.com
Normal adjacent tissues (NATs) of hepatocellular carcinoma (HCC) differ from healthy liver
tissues and their heterogeneity may contain biological information associated with disease …

Identification of serum ferritin-specific nanobodies and development towards a diagnostic immunoassay

Y Hu, J Lin, Y Wang, S Wu, J Wu, H Lv, X Ji… - Biomolecules, 2022 - mdpi.com
Serum ferritin (SF) is an iron-rich protein tightly connected with iron homeostasis, and the
variations are frequently observed in diseased states, including iron-deficiency anemia …