Prostate cancer (CaP) remains the second leading cause of cancer deaths in western men.
CaP mortality results from diverse molecular mechanisms that mediate resistance to the …

Neuropsychiatric genome-wide association studies (GWASs), including those for autism
spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the …

Transcriptome‐wide association study (TWAS) methodologies aim to identify genetic effects
on phenotypes through the mediation of gene transcription. In TWAS, in silico models of …

Combinatorial expression of postsynaptic proteins underlies synapse diversity within and
between neuron types. Thus, characterization of neuron-type-specific postsynaptic …

The omnigenic model posits that genetic risk for traits with complex heritability involves
cumulative effects of peripheral genes on mechanistic" core genes," suggesting that in a …

Summary Most human Transcription factors (TFs) genes encode multiple protein isoforms
differing in DNA binding domains, effector domains, or other protein regions. The global …

A core problem in genetics is molecular quantitative trait locus (QTL) mapping, in which
genetic variants associated with changes in the molecular phenotypes are identified. One of …

Bipolar disorder (BD) is a leading contributor to the global burden of disease. Despite high
heritability (60-80%), the majority of the underlying genetic determinants remain unknown …

Circadian rhythms result from cell-intrinsic timing mechanisms that impact health and
disease1, 2. To date, however, neural circadian research has largely focused on the …

Background Sex-differential biology may contribute to the consistently male-biased
prevalence of autism spectrum disorder (ASD). Gene expression differences between males …