Hypertension, neurovascular dysfunction, and cognitive impairment
MM Santisteban, C Iadecola, D Carnevale - Hypertension, 2023 - Am Heart Assoc
Hypertension affects a significant proportion of the adult and aging population and
represents an important risk factor for vascular cognitive impairment and late-life dementia …
represents an important risk factor for vascular cognitive impairment and late-life dementia …
[HTML][HTML] The role of inflammasomes in vascular cognitive impairment
There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …
Microglial activation and blood–brain barrier permeability in cerebral small vessel disease
Cerebral small vessel disease (SVD) is a major cause of stroke and dementia. The
underlying pathogenesis is poorly understood, but both neuroinflammation and increased …
underlying pathogenesis is poorly understood, but both neuroinflammation and increased …
Cardiovascular comorbidities, inflammation, and cerebral small vessel disease
LE Evans, JL Taylor, CJ Smith… - Cardiovascular …, 2021 - academic.oup.com
Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive
impairment and affects all levels of the brain's vasculature. Features include diverse …
impairment and affects all levels of the brain's vasculature. Features include diverse …
[HTML][HTML] The use of neuroimaging techniques in the early and differential diagnosis of dementia
L Chouliaras, JT O'Brien - Molecular Psychiatry, 2023 - nature.com
Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …
disease modifying treatment for any of the most common types of dementia such as …
Framework for clinical trials in cerebral small vessel disease (FINESSE): a review
Importance Cerebral small vessel disease (SVD) causes a quarter of strokes and is the most
common pathology underlying vascular cognitive impairment and dementia. An important …
common pathology underlying vascular cognitive impairment and dementia. An important …
[HTML][HTML] Neuroinflammation as a mechanism linking hypertension with the increased risk of Alzheimer's disease
E Bajwa, A Klegeris - Neural Regeneration Research, 2022 - journals.lww.com
Alzheimer's disease, the most common type of dementia among older adults, currently
cannot be prevented or effectively treated. Only a very small percentage of Alzheimer's …
cannot be prevented or effectively treated. Only a very small percentage of Alzheimer's …
[HTML][HTML] The underlying role of the glymphatic system and meningeal lymphatic vessels in cerebral small vessel disease
Y Tian, M Zhao, Y Chen, M Yang, Y Wang - Biomolecules, 2022 - mdpi.com
There is a growing prevalence of vascular cognitive impairment (VCI) worldwide, and most
research has suggested that cerebral small vessel disease (CSVD) is the main contributor to …
research has suggested that cerebral small vessel disease (CSVD) is the main contributor to …
Imaging neuroinflammation in neurodegenerative disorders
Neuroinflammation plays a major role in the etiopathology of neurodegenerative diseases,
including Alzheimer and Parkinson diseases, frontotemporal lobar degeneration, and …
including Alzheimer and Parkinson diseases, frontotemporal lobar degeneration, and …
[HTML][HTML] Modifiable and non-modifiable risk factors of dementia on midlife cerebral small vessel disease in cognitively healthy middle-aged adults: the PREVENT …
A Low, MA Prats-Sedano, E McKiernan… - Alzheimer's research & …, 2022 - Springer
Background Considerable overlap exists between the risk factors of dementia and cerebral
small vessel disease (SVD). However, studies remain limited to older cohorts wherein …
small vessel disease (SVD). However, studies remain limited to older cohorts wherein …