Hypertension represents a major common cardiovascular risk factor. Optimal control of high
blood pressure levels is recommended to reduce the global burden of hypertensive …

Phthalazine, a structurally and pharmacologically versatile nitrogen-containing heterocycle,
has gained more attention from medicinal chemists in the design and synthesis of novel …

In spite of all the medical progress, hypertension remains a highly prevalent chronic disease
worldwide, contributing importantly to cardiovascular morbidity and mortality in Europe 1 …

High blood pressure is a major contributor to the global burden of disease and discovering
novel causal pathways of blood pressure regulation has been challenging. We tested blood …

Phthalazinones are an important kind of nitrogen atom containing heterocyclic compounds
due to their synthetic and pharmacological versatility. This fused heterocycle system …

Aims Arterial hypertension is an important cardiovascular risk factor. A substantial proportion
of patients show resistance to antihypertensive treatment but poor adherence to medication …

An adequate control of blood pressure is essential to reduce the risk of target organ
damages and cardiovascular events in patients with hypertension. Yet, it is well recognized …

Hypertension among HIV-positive populations has emerged as a new threat to the health
and well being of people living with HIV, particularly among those receiving antiretroviral …

Today the management of resistant hypertension is a critical health problem: the main
difficulty on this field is the discrimination of cases of poor therapeutic adherence from cases …

Heart failure, be it with preserved or reduced left ventricular function, is the cardiovascular
epidemic of the 21st century, 1–4 and it thus appropriate to devote a whole issue of the …