Heart disease remains the leading cause of death and disability in the Western world.
Current therapies aim at treating the symptoms rather than the subcellular mechanisms …

Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a
heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac …

Acute heart failure (HF) and in particular, cardiogenic shock are associated with high
morbidity and mortality. A therapeutic dilemma is that the use of positive inotropic agents …

Rationale: The Calcium Up-Regulation by Percutaneous Administration of Gene Therapy In
Cardiac Disease (CUPID 1) study was a phase 1/phase 2 first-in-human clinical gene …

Calcium (Ca2+) is a critical regulator of cardiac myocyte function. Principally, Ca2+ is the
link between the electrical signals that pervade the heart and contraction of the myocytes to …

Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

Heart failure is a leading cause of death in industrialized nations especially in an aging
population. The recent improvements in cardiac revascularization therapy reduced death …

Cardiac myocyte function is dependent on the synchronized movements of Ca2+ into and
out of the cell, as well as between the cytosol and sarcoplasmic reticulum. These …

Aims It is generally accepted that post-MI heart failure (HF) changes a variety of aspects of
sarcoplasmic reticular Ca2+ fluxes but for some aspects there is disagreement over whether …