Tetrahedral framework nucleic acids reestablish immune tolerance and restore saliva secretion in a sjogren's syndrome mouse model
S Gao, Y Wang, Y Li, D Xiao, Y Lin… - ACS Applied Materials …, 2021 - ACS Publications
As one of the most frequent autoimmune diseases, Sjogren's syndrome (SS) is
characterized by overactive lymphocytic infiltration in the exocrine glands, with ensuing dry …
characterized by overactive lymphocytic infiltration in the exocrine glands, with ensuing dry …
Interactions of Cells and Biomaterials for Nerve Tissue Engineering: Polymers and Fabrication
ME Harley-Troxell, R Steiner, RC Advincula… - Polymers, 2023 - mdpi.com
Neural injuries affect millions globally, significantly impacting their quality of life. The inability
of these injuries to heal, limited ability to regenerate, and the lack of available treatments …
of these injuries to heal, limited ability to regenerate, and the lack of available treatments …
Delivery Route Considerations for Designing Antigen‐Specific Biomaterial Strategies to Combat Autoimmunity
MA Ackun-Farmmer, CM Jewell - Advanced nanobiomed …, 2023 - Wiley Online Library
Disease‐modifying drugs and biologics used to treat autoimmune diseases, although
promising, are non‐curative. As the field moves toward development of new approaches to …
promising, are non‐curative. As the field moves toward development of new approaches to …
Tuning innate immune function using microneedles containing multiple classes of toll-like receptor agonists
Microneedle arrays (MNAs) are patches displaying hundreds of micron-scale needles that
can penetrate skin. As a result, these arrays efficiently and painlessly access this immune …
can penetrate skin. As a result, these arrays efficiently and painlessly access this immune …
Preparation of degradable and transformable core–corona-type particles that control cellular uptake by thermal shape change
S Komatsu, S Yamada, A Kikuchi - ACS Biomaterials Science & …, 2024 - ACS Publications
Particle–cell interactions, such as cellular uptake, vary depending on the particle size,
shape, and surface properties. By dynamic control of the physical properties of particles …
shape, and surface properties. By dynamic control of the physical properties of particles …
Biomaterial-enabled induction of pancreatic-specific regulatory T cells through distinct signal transduction pathways
Autoimmune diseases—where the immune system mistakenly targets self-tissue—remain
hindered by non-specific therapies. For example, even molecularly specific monoclonal …
hindered by non-specific therapies. For example, even molecularly specific monoclonal …
Synthetic Organic Materials for Targeting Immunotherapies to Lymph Nodes
CJ Bridgeman, R Shen, RA McIlvaine… - Chemistry of …, 2024 - ACS Publications
Immunotherapies have yielded tremendous advances over the last three decades. However,
even the most promising therapies, for example, monoclonal antibodies, require systemic …
even the most promising therapies, for example, monoclonal antibodies, require systemic …
Application of Mannose‐Functionalized Microgel as a Novel Vaccine Delivery Platform for Subunit Vaccines
Y Pan, Y Qi, X Li, S Luan… - Advanced Functional …, 2021 - Wiley Online Library
The recent outbreaks of a series of new infectious diseases have highlighted the pressing
need to develop efficacious countermeasures, including preventive vaccines. Subunit …
need to develop efficacious countermeasures, including preventive vaccines. Subunit …
Engineering metabolism to modulate immunity
SM Kapnick, CA Martin, CM Jewell - Advanced Drug Delivery Reviews, 2023 - Elsevier
Metabolic programming and reprogramming have emerged as pivotal mechanisms for
altering immune cell function. Thus, immunometabolism has become an attractive target …
altering immune cell function. Thus, immunometabolism has become an attractive target …
Spatial delivery of immune cues to lymph nodes to define therapeutic outcomes in cancer vaccination
JI Andorko, SJ Tsai, JM Gammon, ST Carey… - Biomaterials …, 2022 - pubs.rsc.org
Recently approved cancer immunotherapies–including CAR-T cells and cancer vaccination,–
show great promise. However, these technologies are hindered by the complexity and cost …
show great promise. However, these technologies are hindered by the complexity and cost …