Methadone recycling sustains drug reservoir in tissue

OA Linares, J Fudin, A Daly, WE Schiesser… - Journal of Pain & …, 2015 - Taylor & Francis
We hypothesize that there is a tissue store of methadone content in humans that is not
directly accessible, but is quantifiable. Further, we hypothesize the mechanism by which …

Feasibility and utility of the individualized hydrocodone therapy based on phenotype, pharmacogenetics, and pharmacokinetic dosing

OA Linares, M Tod, AL Daly… - The Clinical Journal of …, 2016 - journals.lww.com
We do not disagree that “in mice,” as concluded by Navani and Yoburn, 18 NHC
administered through subcutaneous, intrathecal, and intracerebroventricular routes …