Submucosal glands contribute to airway surface liquid (ASL), a film that protects all airway
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …

Airway disease currently causes most of the morbidity and mortality in patients with cystic
fibrosis (CF). However, understanding the pathogenesis of CF lung disease and developing …

One of the main functions of the airway epithelium is to inactivate and remove infectious
particles from inhaled air and thereby prevent infection of the distal lung. This function is …

The mechanisms underlying the development and natural progression of the airway mucus
defect in cystic fibrosis (CF) remain largely unclear. New animal models of CF, coupled with …

Airway submucosal glands produce the mucus that lines the upper airways to protect them
against insults. This review summarizes evidence for two forms of gland secretion, and …

The development of effective therapies for cystic fibrosis (CF) requires animal models that
can appropriately reproduce the human disease phenotype. CF mouse models have …

Cystic fibrosis (CF) is caused by dysfunction of the CF transmembrane conductance
regulator (CFTR), an anion channel whose dysfunction leads to chronic bacterial and fungal …

Submucosal glands of the tracheobronchial airways provide the important functions of
secreting mucins, antimicrobial substances, and fluid. This review focuses on the ionic …

During airway branching morphogenesis, focal regions of FGF-10 expression in the
pulmonary mesenchyme are thought to provide a local guidance cue, which promotes …

Submucosal glands line the cartilaginous airways and produce most of the antimicrobial
mucus that keeps the airways sterile. The glands are defective in cystic fibrosis (CF), but how …