Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …

Despite enormous development in the field of drug development, cancer still remains
elusive. Compromised immunity stands as a roadblock to the successful pharmacological …

Human telomerase is a RNA–protein complex that extends the 3′ end of linear
chromosomes by synthesizing multiple copies of the telomeric repeat TTAGGG. Its activity is …

Nitric Oxide (NO) is a highly diffusible, ubiquitous signaling molecule and a free radical that
is naturally synthesized by our body. The pleiotropic effects of NO in biological systems are …

Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …

The main aim of the present systematic review was to summarize the most frequently used
telomerase regulators with an impact on aging and cancer that are referred to in in vitro and …

Aging is a natural process that determined by a functional decline in cells and tissues as
organisms are growing old, resulting in an increase at risk of disease and death. To this end …

Telomerase is a ribonucleoprotein (RNP) responsible for the maintenance of chromosomal
integrity by stabilizing telomere length. Telomerase is a widely expressed hallmark …

Telomere dynamics play a crucial role in the maintenance of chromosome integrity; changes
in telomere length may thus contribute to the development of various diseases including …

Bladder cancer (BC) is the 10th most frequent cancer in the world. The initial diagnosis and
surveillance of BC require a combination of invasive and non-invasive methods, which are …