Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …

Our understanding of serrated colorectal polyps has increased dramatically over the past
two decades and has led to a modern classification scheme for these lesions. Sessile …

Background & Aims Traditional serrated adenomas (TSAs) are rare colorectal polyps with
unique histologic features. Fusions in R-spondin genes have been found in TSAs, but it is …

Here, we provide an up-to-date review of the histopathology and molecular pathology of
serrated colorectal lesions. First, we introduce the updated contents of the 2019 World …

The serrated neoplasia pathway constitutes an “alternative route” to colorectal cancer
(CRC), and sessile serrated lesions with dysplasia (SSLDs) are an intermediate step …

Aims Traditional serrated adenoma (TSA) is an uncommon type of colorectal serrated polyp.
RSPO fusions, which potentiate WNT signalling, are common and characteristic genetic …

The 2019 WHO classification of digestive system tumors significantly reformed the
classificatory definition of serrated lesions of the colorectal mucosa and added new …

Background Traditional serrated adenoma (TSA) is the least common type of colorectal
serrated polyp, which exhibits considerable morphological and molecular diversity. Methods …

Background Recent studies have shown that traditional serrated adenoma (TSA) can be
classified into BRAF and KRAS subtypes. Here, we examined the clinicopathological and …

Background & Aims Colorectal cancer (CRC) is thought to arise when the cumulative
mutational burden within colonic crypts exceeds a certain threshold that leads to clonal …