[HTML][HTML] Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose?
Recent evidence indicates that ionizing radiation can enhance immune responses to
tumors. Advances in radiation delivery techniques allow hypofractionated delivery of …
tumors. Advances in radiation delivery techniques allow hypofractionated delivery of …
[HTML][HTML] Low dose ionizing radiation effects on the immune system
K Lumniczky, N Impens, G Armengol, S Candéias… - Environment …, 2021 - Elsevier
Ionizing radiation interacts with the immune system in many ways with a multiplicity that
mirrors the complexity of the immune system itself: namely the need to maintain a delicate …
mirrors the complexity of the immune system itself: namely the need to maintain a delicate …
Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade
RB Patel, R Hernandez, P Carlson… - Science translational …, 2021 - science.org
Molecular and cellular effects of radiotherapy on tumor microenvironment (TME) can help
prime and propagate antitumor immunity. We hypothesized that delivering radiation to all …
prime and propagate antitumor immunity. We hypothesized that delivering radiation to all …
Radiotherapy and immunotherapy: a beneficial liaison?
Investigations into the interaction between radiotherapy and the host immune system have
uncovered new mechanisms that can potentially be exploited to improve the efficacy of …
uncovered new mechanisms that can potentially be exploited to improve the efficacy of …
Immunomodulation of the tumor microenvironment: turn foe into friend
H Locy, S De Mey, W De Mey, M De Ridder… - Frontiers in …, 2018 - frontiersin.org
Immunotherapy, where the patient's own immune system is exploited to eliminate tumor
cells, has become one of the most prominent new cancer treatment options in the last …
cells, has become one of the most prominent new cancer treatment options in the last …
Safety of combining radiotherapy with immune-checkpoint inhibition
Immune-checkpoint inhibitors targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4),
programmed cell death protein 1 (PD-1), or programmed cell death 1 ligand 1 (PD-L1) have …
programmed cell death protein 1 (PD-1), or programmed cell death 1 ligand 1 (PD-L1) have …
A review on lymphocyte radiosensitivity and its impact on radiotherapy
H Paganetti - Frontiers in Oncology, 2023 - frontiersin.org
It is well known that radiation therapy causes lymphopenia in patients and that this is
correlated with a negative outcome. The mechanism is not well understood because …
correlated with a negative outcome. The mechanism is not well understood because …
[HTML][HTML] The promise of combining radiation therapy with immunotherapy
The development of immunotherapy in oncology builds upon many years of scientific
investigation into the cellular mechanics underlying interactions between tumor cells and …
investigation into the cellular mechanics underlying interactions between tumor cells and …
Role of radiation therapy in modulation of the tumor stroma and microenvironment
In recent decades, there has been substantial growth in our understanding of the immune
system and its role in tumor growth and overall survival. A central finding has been the cross …
system and its role in tumor growth and overall survival. A central finding has been the cross …
Radiation sensitivity of human and murine peripheral blood lymphocytes, stem and progenitor cells
D Heylmann, F Rödel, T Kindler, B Kaina - Biochimica et Biophysica Acta …, 2014 - Elsevier
Immunodeficiency is a severe side effect of radiation therapy, notably at high radiation
doses. It may also impact healthy individuals exposed to environmental ionizing radiation …
doses. It may also impact healthy individuals exposed to environmental ionizing radiation …