Canadian Association of Gastroenterology clinical practice guideline on the management of bile acid diarrhea

DC Sadowski, M Camilleri, WD Chey… - Journal of the …, 2020 - academic.oup.com
Abstract Background and Aims Chronic diarrhea affects about 5% of the population overall.
Altered bile acid metabolism is a common but frequently undiagnosed cause. Methods We …

Bile acid–gut microbiota crosstalk in irritable bowel syndrome

Y Gu, L Li, M Yang, T Liu, X Song, X Qin… - Critical Reviews in …, 2023 - Taylor & Francis
Irritable bowel syndrome (IBS) is a common disorder of gut–brain interaction with an
increasing prevalence, and its precise aetiology remains unclear. Gut microbiota dysbiosis …

Efficacy and safety of colesevelam for the treatment of bile acid diarrhoea: a double-blind, randomised, placebo-controlled, phase 4 clinical trial

C Borup, L Vinter-Jensen, SPG Jørgensen… - The Lancet …, 2023 - thelancet.com
Background Bile acid diarrhoea is a common but overlooked cause of chronic watery
diarrhoea. Plasma 7α-hydroxy-4-cholesten-3-one (C4) is an alternative to the gold standard …

Disordered gut microbiota correlates with altered fecal bile acid metabolism and post-cholecystectomy diarrhea

Y Xu, H Jing, J Wang, S Zhang, Q Chang, Z Li… - Frontiers in …, 2022 - frontiersin.org
Post-cholecystectomy diarrhea (PCD) is a common complication of gallbladder removal, and
gut microbiota changes have been determined in PCD patients. Bile acid diarrhea (BAD) is …

Gut microbiota alteration after cholecystectomy contributes to post-cholecystectomy diarrhea via bile acids stimulating colonic serotonin

Y Xu, J Wang, X Wu, H Jing, S Zhang, Z Hu, L Rao… - Gut …, 2023 - Taylor & Francis
Post-cholecystectomy diarrhea (PCD) is highly prevalent among outpatients with
cholecystectomy, and gut microbiota alteration is correlated with it. However, how and to …

The impact of treatment with bile acid sequestrants on quality of life in patients with bile acid diarrhoea

A Kumar, N Galbraith, HO Al-Hassi, M Jain… - BMC …, 2022 - Springer
Background Bile acid diarrhoea (BAD) can be severely debilitating and negatively affect
patients' quality of life (QoL). We carried out a multi-centre prospective study exploring QoL …

Chronic loose stools following right‐sided hemicolectomy for colon cancer and the association with bile acid malabsorption and small intestinal bacterial overgrowth

HM Larsen, K Krogh, M Borre, T Gregersen… - Colorectal …, 2023 - Wiley Online Library
Aim Patients treated with right‐sided hemicolectomy for colon cancer may suffer from long‐
term bowel dysfunction, including loose stools, urgency and faecal incontinence. The …

Systematic review with meta‐analysis: the prevalence of bile acid malabsorption and response to colestyramine in patients with chronic watery diarrhoea and previous …

L Ruiz‐Campos, JP Gisbert, M Ysamat… - Alimentary …, 2019 - Wiley Online Library
Background A limited number of small‐sized studies suggest that bile acid diarrhoea is
frequent in patients with chronic watery diarrhoea and previous cholecystectomy. Aim To …

Clinical evaluation and treatment of chronic bowel symptoms following cancer in the colon and pelvic organs

HM Larsen, M Borre, P Christensen… - Acta …, 2019 - Taylor & Francis
Background: Chronic gastrointestinal symptoms are common among patients surviving
surgery and/or radio-/chemotherapy for cancer in the pelvic organs. However, little is known …

Rates of bile acid diarrhoea after cholecystectomy: a multicentre audit

A Farrugia, JA Attard, S Hanmer, S Bullock… - World journal of …, 2021 - Springer
Introduction Bile acid diarrhoea (BAD) can occur due to disruption to the enterohepatic
circulation, eg following cholecystectomy. Post-cholecystectomy diarrhoea has been …