Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Abstract The INK4b–ARF–INK4a locus encodes two members of the INK4 family of cyclin-
dependent kinase inhibitors, p15 INK4b and p16 INK4a, and a completely unrelated protein …

The accurate reconstruction of gene regulatory networks from large scale molecular profile
datasets represents one of the grand challenges of Systems Biology. The Algorithm for the …

We developed a novel system to create DNA double-strand breaks (DSBs) at defined
endogenous sites in the human genome, and used this system to detect protein recruitment …

The E2F1 transcription factor is a critical downstream target of the tumor suppressor pRB.
The retinoblastoma (RB) pathway is often inactivated in human tumors, resulting in …

TBX3, a member of the ancient and evolutionary conserved T-box transcription factor family,
is a critical developmental regulator of several structures including the heart, mammary …

Deregulation of the transcription factor E2F-1 is a common event in most human cancers.
Paradoxically, E2F-1 has been shown to have the ability to induce both cell cycle …

Tumor development is dependent upon the inactivation of two key tumor-suppressor
networks, p16Ink4a–cycD/cdk4–pRB–E2F and p19Arf–mdm2–p53, that regulate cellular …

Matrine is a major component of Sophora Flavescens and has been reported to stimulate
differentiation of erythroleukemia cells. Here we show that matrine inhibits cell proliferation …

Cellular senescence (CS) is closely related to tumor progression. However, the studies
about CS genes across human cancers have not explored the relationship between cancer …