Bioactive lipids, inflammation and chronic diseases
A Leuti, D Fazio, M Fava, A Piccoli, S Oddi… - Advanced Drug Delivery …, 2020 - Elsevier
Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …
cellular and molecular processes involved in health and disease, of which inflammation …
3‐Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease
E Brouillet, C Jacquard, N Bizat… - Journal of …, 2005 - Wiley Online Library
Huntington's disease (HD) is a neurodegenerative disorder caused by a mutation in the
gene encoding Huntingtin. The mechanisms underlying the preferential degeneration of the …
gene encoding Huntingtin. The mechanisms underlying the preferential degeneration of the …
Preclinical safety of RNAi-mediated HTT suppression in the rhesus macaque as a potential therapy for Huntington's disease
To date, a therapy for Huntington's disease (HD), a genetic, neurodegenerative disorder,
remains elusive. HD is characterized by cell loss in the basal ganglia, with particular …
remains elusive. HD is characterized by cell loss in the basal ganglia, with particular …
Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy
TL Spires, JD Orne, K SantaCruz, R Pitstick… - The American journal of …, 2006 - Elsevier
Neurofibrillary tangles form in a specific spatial and temporal pattern in Alzheimer's disease.
Although tangle formation correlates with dementia and neuronal loss, it remains unknown …
Although tangle formation correlates with dementia and neuronal loss, it remains unknown …
Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice
Huntington's disease (HD) is a fatal neurodegenerative disease caused by mutant huntingtin
(htt) protein, and there are currently no effective treatments. Recently, we and others …
(htt) protein, and there are currently no effective treatments. Recently, we and others …
Minocycline in neurodegenerative and psychiatric diseases: an update
D Romero‐Miguel, N Lamanna‐Rama… - European Journal of …, 2021 - Wiley Online Library
Background and purpose Minocycline is a broad‐spectrum antibiotic, effective as a chronic
treatment for recurrent bacterial infections. Beyond its antibiotic action, minocycline also has …
treatment for recurrent bacterial infections. Beyond its antibiotic action, minocycline also has …
3-Nitropropionic acid as a tool to study the mechanisms involved in Huntington's disease: past, present and future
I Túnez, I Tasset, V Pérez-De La Cruz, A Santamaría - Molecules, 2010 - mdpi.com
Huntington's disease (HD) is an inheritable autosomal-dominant disorder whose causal
mechanisms remain unknown. Experimental models have begun to uncover these …
mechanisms remain unknown. Experimental models have begun to uncover these …
Immunomodulatory properties of antibiotics
R Nau, SC Tauber - Current molecular pharmacology, 2008 - ingentaconnect.com
There is growing evidence that certain antibiotics exert their beneficial effects not only by
killing or inhibiting the growth of bacterial pathogens but also indirectly by …
killing or inhibiting the growth of bacterial pathogens but also indirectly by …
Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline
MJ Casarejos, J Menendez, RM Solano… - Journal of …, 2006 - Wiley Online Library
Parkinson's disease is a neurodegenerative disorder which is in most cases of unknown
etiology. Mutations of the Park‐2 gene are the most frequent cause of familial parkinsonism …
etiology. Mutations of the Park‐2 gene are the most frequent cause of familial parkinsonism …
Therapeutic advances in Huntington's disease
KM Shannon, A Fraint - Movement Disorders, 2015 - Wiley Online Library
Huntington's disease is a rare hereditary degenerative disease with a wide variety of
symptoms that encompass movement, cognition, and behavior. The genetic mutation that …
symptoms that encompass movement, cognition, and behavior. The genetic mutation that …