Phase separation in viral infections

H Li, C Ernst, M Kolonko-Adamska… - Trends in …, 2022 - cell.com
Viruses rely on the reprogramming of cellular processes to enable efficient viral replication;
this often requires subcompartmentalization within the host cell. Liquid–liquid phase …

Liquid phase partitioning in virus replication: observations and opportunities

C Wu, AS Holehouse, DW Leung… - Annual Review of …, 2022 - annualreviews.org
Viruses frequently carry out replication in specialized compartments within cells. The effect
of these structures on virus replication is poorly understood. Recent research supports …

[HTML][HTML] Phase separation in cancer: from the impacts and mechanisms to treatment potentials

Q Peng, S Tan, L Xia, N Wu, L Oyang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Cancer is a public health problem of great concern, and it is also one of the main causes of
death in the world. Cancer is a disease characterized by dysregulation of diverse cellular …

Defining basic rules for hardening influenza A virus liquid condensates

TA Etibor, S Vale-Costa, S Sridharan, D Brás, I Becher… - Elife, 2023 - elifesciences.org
In biological systems, liquid and solid-like biomolecular condensates may contain the same
molecules but their behaviour, including movement, elasticity, and viscosity, is different on …

Co‐opted cytosolic proteins form condensate substructures within membranous replication organelles of a positive‐strand RNA virus

W Lin, PD Nagy - New Phytologist, 2024 - Wiley Online Library
Positive‐strand RNA viruses co‐opt organellar membranes for biogenesis of viral replication
organelles (VROs). Tombusviruses also co‐opt pro‐viral cytosolic proteins to VROs. It is …

[HTML][HTML] Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication

BA Chau, V Chen, AW Cochrane, LJ Parent… - Cell Reports, 2023 - cell.com
The leap of retroviruses and coronaviruses from animal hosts to humans has led to two
ongoing pandemics and tens of millions of deaths worldwide. Retrovirus and coronavirus …

Liquid-liquid phase separation in viral function

X Zhang, R Zheng, Z Li, J Ma - Journal of Molecular Biology, 2023 - Elsevier
An emerging set of results suggests that liquid-liquid phase separation (LLPS) is the basis
for the formation of membrane-less compartments in cells. Evidence is now mounting that …

[HTML][HTML] TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

J Ren, S Wang, Z Zong, T Pan, S Liu, W Mao… - Nature …, 2024 - nature.com
Viruses, as opportunistic intracellular parasites, hijack the cellular machinery of host cells to
support their survival and propagation. Numerous viral proteins are subjected to host …

Flexibility of the rotavirus NSP2 C-terminal region supports factory formation via liquid-liquid phase separation

SL Nichols, EM Nilsson, H Brown-Harding… - Journal of …, 2023 - Am Soc Microbiol
Many viruses sequester the materials needed for their replication into discrete subcellular
factories. For rotaviruses (RVs), these factories are called viroplasms, and they are formed in …

[HTML][HTML] Scaffolding viral protein NC nucleates phase separation of the HIV-1 biomolecular condensate

A Monette, M Niu, MN Asser, RJ Gorelick, AJ Mouland - Cell Reports, 2022 - cell.com
Membraneless biomolecular condensates (BMCs) contribute to the replication of a growing
number of viruses but remain to be functionally characterized. Previously, we demonstrated …