The hepatic pigment accumulated as a consequence of the self-catalyzed destruction of
cytochrome P-450 by norethisterone (17-hydroxy-19-nor-17 alpha-pregn-4-en-20-yn-3-one) …

Women of childbearing potential were given single 1.5 mg oral doses of 14C-dl-, d-or l-
norgestrel (Ng). Blood specimens were obtained at selected time intervals. Drug related …

A mixture of 2-3 H and 4-14 C-mestranol was administered orally to five women and 2-3 H-
mestranol alone to one woman. Reactions involving position 2 were extensive as judged by …

Publisher Summary This chapter is primarily concerned with the recent reports on substrate
dependent enantioselective metabolism of chiral CNS agents, autonomic, and …

Abstract Single intragastric 0.5 mg/kg doses of 14 Cd-norgestrel-3-oxime-17-acetate were
given to female rhesus monkeys. Rapid absorption was evidenced by peak concentrations …

Norethisterone and, to a lesser extent, d-norgestrel are metabolically activated by rat liver
microsomal enzymes to intermediates which are capable of irreversibly binding to proteins …

Following single intragastric doses of d-and dl-[24C] norgestrel (Ng), rhesus monkeys
excreted 29.5+/-2.0 (SE) and 52.6+/-5.4% of the administered radioactivity in urine. Fecal …

The metabolic fate of chlormadinone acetate (17α-acetoxy-6-chloro-4, 6-pregnadiene-3, 20-
dione; CAP) was studied in intact and biliary fistula baboons. The steroid was labeled with 3 …

The rates of metabolism of synthetic gestagens derived from 19-nortestosterone by rabbit
liver tissue in vitro were compared. Over a period of 1 h norethisterone was metabolised as …

The title of this article expresses a position: It implies that drug metabolism is part of drug
safety evaluation. To those in the pharmaceutical industry this may appear quite natural …