Animal models of acute exacerbation of pulmonary fibrosis

X Ye, M Zhang, H Gu, M Liu, Y Zhao, Y Shi, S Wu… - Respiratory …, 2023 - Springer
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive scarring interstitial lung disease
with an unknown cause. Some patients may experience acute exacerbations (AE), which …

Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis

S Zhou, J Zhu, PK Zhou, Y Gu - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Radiation-induced pulmonary fibrosis (RIPF) is a chronic and progressive respiratory tract
disease characterized by collagen deposition. The pathogenesis of RIPF is still unclear …

Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis

LR Conroy, HA Clarke, DB Allison, SS Valenca… - Nature …, 2023 - nature.com
Matrix assisted laser desorption/ionization imaging has greatly improved our understanding
of spatial biology, however a robust bioinformatic pipeline for data analysis is lacking. Here …

PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis

Y Geng, L Li, J Yan, K Liu, A Yang, L Zhang… - Nature …, 2022 - nature.com
Pulmonary fibrosis is a chronic interstitial lung disease that causes irreversible and
progressive lung scarring and respiratory failure. Activation of fibroblasts plays a central role …

Anthelmintic nitazoxanide protects against experimental pulmonary fibrosis

XY Chen, YC Dong, YY Yu, M Jiang… - British Journal of …, 2023 - Wiley Online Library
Abstract Background and Purpose Nitazoxanide is a therapeutic anthelmintic drug. Our
previous studies found that nitazoxanide and its metabolite tizoxanide activated adenosine …

Advancing the boundaries of immunotherapy in lung adenocarcinoma with idiopathic pulmonary fibrosis by a biomimetic proteinoid enabling selective endocytosis

A Jiang, X Zheng, S Yan, J Yan, Y Yao, W He - ACS nano, 2024 - ACS Publications
The coexistence of lung adenocarcinoma (LUAD) with idiopathic pulmonary fibrosis (IPF),
which has been extensively documented as a prominent risk factor for checkpoint inhibitor …

The role of PD-1/PD-L1 axis in idiopathic pulmonary fibrosis: Friend or foe?

A Jiang, N Liu, J Wang, X Zheng, M Ren… - Frontiers in …, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease with a bleak
prognosis. Mounting evidence suggests that IPF shares bio-molecular similarities with lung …

Insights on the mechanism of bleomycin to induce lung injury and associated in vivo models: a review

BL Ayilya, A Balde, M Ramya, S Benjakul… - International …, 2023 - Elsevier
Acute lung injury leads to the development of chronic conditions such as idiopathic
pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), asthma as well as …

Promises and challenges of cell-based therapies to promote lung regeneration in idiopathic pulmonary fibrosis

A Egea-Zorrilla, L Vera, B Saez, A Pardo-Saganta - Cells, 2022 - mdpi.com
The lung epithelium is constantly exposed to harmful agents present in the air that we
breathe making it highly susceptible to damage. However, in instances of injury to the lung, it …

PRDX1 negatively regulates bleomycin-induced pulmonary fibrosis via inhibiting the epithelial-mesenchymal transition and lung fibroblast proliferation in vitro and in …

HN Sun, CX Ren, DH Lee, WH Wang, XY Guo… - Cellular & Molecular …, 2023 - Springer
Background Pulmonary fibrosis is a major category of end-stage changes in lung diseases,
characterized by lung epithelial cell damage, proliferation of fibroblasts, and accumulation of …