The sine oculis (SIX) family of transcription factors are key regulators of developmental
processes during embryogenesis. Members of this family control gene expression to …

Branchiootorenal spectrum disorder (BORSD) is a group of rare autosomal dominant entities
characterized by branchiogenic malformations, hearing loss (HL) and renal anomalies. It …

Abstract Branchio-oto-renal (BOR)/branchio-otic (BO) syndrome is a rare disorder and
exhibits clinically heterogenous phenotypes, marked by abnormalities in the ear, branchial …

Metastasis is the main reason for high mortality in hepatocellular carcinoma (HCC) patients
and the molecular mechanism remains unclear. Therefore, it is important to elucidate the …

Background: Branchio-oto-renal syndrome (BOR) and branchio-oto syndrome (BOS) are
rare autosomal dominant disorders defined by varying combinations of branchial, otic, and …

Polycomb repressive complex 2 has a critical role in the maintenance of bivalent promoters
and is often perturbed in cancer, including neuroendocrine tumors. In this study, we …

The estimated prevalence of permanent bilateral hearing loss (HL) in children is 1.33 per
1000 live births, increasing to 3.5 per 1000 adolescents, presumably reflecting additional …

Branchio-oto-renal syndrome (BOR) is a disorder characterized by hearing loss, and
craniofacial and/or renal defects. Variants in the transcription factor Six1 and its co-factor …

Over 200 genes are known to underlie human congenital hearing loss (CHL). Although
transcriptomic approaches have identified candidate regulators of otic development, little is …

Introduction: The Six1 transcription factor plays important roles in the development of cranial
sensory organs, and point mutations underlie craniofacial birth defects. Because Six1's …