Adeno-associated virus type 2 (AAV2) has gained much interest as a gene delivery vector. A
hallmark of AAV2-mediated gene transfer is an intracellular conformational change of the …

As the clinical experience in adeno-associated viral (AAV) vector-based gene therapies is
expanding, the necessity to better understand and control the host immune responses is …

The first generation of adeno-associated virus (AAV) vectors composed of the naturally
occurring capsids and genomes, although effective in some instances, are unlikely to be …

As gene therapy enters mainstream medicine, it is more important than ever to have a grasp
of exactly how to leverage it for maximum benefit. The development of new targeting …

Moderate noise exposure may cause acute loss of cochlear synapses without affecting the
cochlear hair cells and hearing threshold; thus, it remains" hidden" to standard clinical tests …

One of the most remarkable advancements in medical treatments of corneal diseases in
recent decades has been corneal transplantation. However, corneal transplants, including …

Adeno-associated viral (AAV) vectors are the most efficient in vivo gene transfer tools for
gene therapy applications. Efforts have been made to translate encouraging results in small …

Adeno-Associated Virus based vectors (rAAV) are advantageous for human gene therapy
due to low inflammatory responses, lack of toxicity, natural persistence, and ability to …

Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that regulates cellular
homeostatic processes. Following ligand binding, EGFR activates different downstream …

Proteasome inhibitors (eg, bortezomib, MG132) are known to enhance adeno-associated
virus (AAV) transduction; however, whether this results from pleotropic proteasome inhibition …