Recent clinical trials have shown that the use of replication deficient viral vectors to
genetically modify cells in the retina can be of therapeutic benefit in the treatment of certain …

Astrocytes have crucial functions in the central nervous system (CNS) and are major players
in many CNS diseases. Research on astrocyte‐centered diseases requires efficient and well …

The trabecular meshwork (TM) of the eye is responsible for maintaining physiological
intraocular pressure (IOP). Dysfunction of this tissue results in elevated IOP, subsequent …

Adeno-associated virus (AAV) vectors are important gene delivery tools for the treatment of
many recessively inherited retinal diseases. For example, a wild-type (WT) AAV5 vector can …

Following infection of epithelial tissues, herpes simplex virus 1 (HSV-1) virions travel via
axonal transport to sensory ganglia and establish a lifelong latent infection within neurons …

Heat-shock protein 90 (Hsp90) is a molecular chaperone required for the stability and
function of many signaling proteins that are often activated, mutated or overexpressed in …

Gene therapy of genetically determined diseases, including some pathologies of the
respiratory system, requires an efficient method for transgene delivery. Recombinant adeno …

Viral vectors-based gene therapy is an attractive alternative to common anti-cancer
treatments. In the present studies, AAV serotype 6 vectors were identified to be particularly …

We aimed to develop an anti-angiogenic model for breast cancer by combining (1) siRNA-
based therapy delivered by self-complementary adeno-associated virus serotype 2 …

Capitalizing on liver tropism of adeno-associated viral (AAV) vectors, intravenous vector
administration is commonly used to genetically modify hepatocytes, a strategy currently in …