A guide to complement biology, pathology and therapeutic opportunity

DC Mastellos, G Hajishengallis… - Nature Reviews …, 2024 - nature.com
Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

[HTML][HTML] Glomerulonephritis: immunopathogenesis and immunotherapy

HJ Anders, AR Kitching, N Leung… - Nature Reviews …, 2023 - nature.com
Abstract 'Glomerulonephritis'(GN) is a term used to describe a group of heterogeneous
immune-mediated disorders characterized by inflammation of the filtration units of the kidney …

Insights into new-onset autoimmune diseases after COVID-19 vaccination

M Guo, X Liu, X Chen, Q Li - Autoimmunity reviews, 2023 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has resulted in more than 670 million infections and …

[HTML][HTML] Complement C3a and C3a receptor activation mediates podocyte injuries in the mechanism of primary membranous nephropathy

S Gao, Z Cui, M Zhao - Journal of the American Society of …, 2022 - journals.lww.com
Background The complement system is highly activated in primary membranous
nephropathy (MN). Identifying the complement components that damage podocytes has …

[HTML][HTML] Membranous nephropathy: systems biology-based novel mechanism and traditional Chinese medicine therapy

H Miao, Y Zhang, X Yu, L Zou, Y Zhao - Frontiers in pharmacology, 2022 - frontiersin.org
Membranous nephropathy (MN) is a renal-limited non-inflammatory autoimmune disease in
the glomerulus, which is the second or third main cause of end-stage kidney diseases in …

Pharmacological potential of Astragali Radix for the treatment of kidney diseases

Y Shi, X Shi, M Zhao, S Ma, Y Zhang - Phytomedicine, 2024 - Elsevier
Background With the increasing prevalence of hypertension, diabetes, and obesity, the
incidence of kidney diseases is also increasing, resulting in a serious public burden …

[HTML][HTML] Incidence of new onset glomerulonephritis after SARS-CoV-2 mRNA vaccination is not increased

M Diebold, E Locher, P Boide, A Enzler-Tschudy… - Kidney international, 2022 - Elsevier
Numerous cases of glomerulonephritis manifesting shortly after SARS-CoV-2 vaccination
have been reported, but causality remains unproven. Here, we studied the association …

[HTML][HTML] Novel antigens and clinical updates in membranous nephropathy

R Avasare, N Andeen, L Beck - Annual review of medicine, 2024 - annualreviews.org
Membranous nephropathy (MN), an autoimmune kidney disease and leading cause of
nephrotic syndrome, leads to kidney failure in up to one-third of affected individuals. Most …

[HTML][HTML] Metabolic profiling reveals new serum signatures to discriminate lupus nephritis from systemic lupus erythematosus

Y Zhang, L Gan, J Tang, D Liu, G Chen… - Frontiers in …, 2022 - frontiersin.org
Background Lupus nephritis (LN) occurs in 50% of patients with systemic lupus
erythematosus (SLE), causing considerable morbidity and even mortality. Previous studies …

[HTML][HTML] Novel treatments paradigms: membranous nephropathy

JE Rojas-Rivera, A Ortiz, FC Fervenza - Kidney international reports, 2023 - Elsevier
Primary membranous nephropathy (MN) is a kidney-specific autoimmune glomerular
disease and the leading cause of nephrotic syndrome (NS) in White adults, usually caused …