The architectonics of the mammalian brain arise from a remarkable range of directed cell
migrations, which orchestrate the emergence of cortical neuronal layers and pattern brain …

The formation of the neocortex relies on intracellular and extracellular signaling molecules
that are involved in the sequential steps of corticogenesis, ranging from the proliferation and …

After cell birth, almost all neurons in the mammalian central nervous system migrate. It is
unclear whether and how cell migration is coupled with neurogenesis. Here we report that …

The specification and differentiation of dentate gyrus granule neurons in the hippocampus
require temporally and spatially coordinated actions of both intrinsic and extrinsic molecules …

Neurons, astrocytes and oligodendrocytes arise from CNS progenitor cells at defined times
and locations during development, with transcription factors serving as key determinants of …

δ-Protocadherins constitute a group of cadherins characterized by several conserved motifs
in their cytoplasmic domains. We present a phylogenetic analysis that further divides this …

We showed previously that the proneural genes Neurogenin1 (Ngn1) and Ngn2 are
required to specify the phenotypes of early-and not late-born neurons in the neocortex …

Neurogenins are proneural transcription factors required to specify neuronal identity. Their
overexpression in human pluripotent stem cells rapidly produces cortical-like neurons with …

Embryonic stem (ES) cells form spontaneous aggregates during differentiation, and cell–cell
communication in the aggregates plays an important role in differentiation. The development …

Neurogenin 2 (Ngn2) is a proneural gene involved in neuronal differentiation and subtype
specification in various regions of the nervous system. In the ventral midbrain, Ngn2 is …