Regulated proliferation and cell cycle exit are essential aspects of neurogenesis. The Yap
transcriptional coactivator controls proliferation in a variety of tissues during development …

Transcription factors are key regulators of central nervous system (CNS) development and
brain function. Research in this area has now uncovered a new key player–the nuclear …

Charles Darwin stated,“community in embryonic structure reveals community of descent”.
Thus, to understand how the neocortex emerged during mammalian evolution we need to …

Background The formation of the mammalian central nervous system requires the
establishment of complex neural circuits between a diverse array of neuronal subtypes …

Proneural genes encode evolutionarily conserved basic-helix–loop–helix transcription
factors. In Drosophila, proneural genes are required and sufficient to confer a neural identity …

Abstract Proneural NEUROG2 (neurogenin 2 [Ngn2]) is essential for neuronal commitment,
cell cycle withdrawal, and neuronal differentiation. Although NEUROG2's influence on …

Several transcription factors are essential determinants of a cortical projection neuron
identity, but their mode of action (instructive versus permissive) and downstream genetic …

Since the discovery of radial glia as the source of neurons, their heterogeneity in regard to
neurogenesis has been described by clonal and time-lapse analysis in vitro. However, the …

Accumulating evidence has established a firm role for synaptic plasticity in the pathogenesis
of neuropathic pain. Recent advances have highlighted the importance of dendritic spine …

Appropriate neurogenesis and patterning of the forebrain requires the transcription factor
Pax6, yet it is largely unknown how Pax6 exerts its effects at the molecular level. To …