In recent years, the biological role of changes in physical factors in carcinogenesis and
progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is …

Rather than primary solid tumors, metastasis is one of the hallmarks of most cancer deaths.
Metastasis is a multistage event in which cancer cells escape from the primary tumor survive …

The complex immunosuppressive tumour microenvironment (TME) and lack of tumour-
specific targets hinder the application of chimeric antigen receptor (CAR) T cells in the …

Ovarian cancer is a malignant tumor of the female reproductive system, with a very poor
prognosis and high mortality rates. Chemotherapy and radiotherapy are the most common …

Simple Summary Since the targeting of a single pro-angiogenic factor fails to improve
oncological disease outcome, significant efforts have been made to identify new pro …

Chronic inflammation is a known risk factor for gastrointestinal cancer. The evidence that
nonsteroidal anti-inflammatory drugs suppress the incidence, growth, and metastasis of …

Simple Summary Ovarian cancer is a highly lethal female malignancy with high rates of
advanced stage and recurrent disease. Ovarian cancer is characterized as poorly …

Monocytes in peripheral blood circulation are the precursor of essential cells that control
tumor progression, that include tumor-associated macrophages (TAMs), dendritic cells …

Phagocytosis is a key macrophage function, but how phagocytosis shapes tumor-associated
macrophage (TAM) phenotypes and heterogeneity in solid tumors remains unclear. Here …

Osteopontin (OPN) is a multifunctional phosphorylated protein. It is widely involved in solid
tumor progression, such as intensification of macrophage recruitment, inhibition of T-cell …