[HTML][HTML] Epithelial-Mesenchymal Transition in Age-Associated Thymic Involution: Mechanisms and Therapeutic Implications

J Yang, J Liu, J Liang, F Li, W Wang, H Chen… - Ageing Research …, 2023 - Elsevier
The thymus is a critical immune organ with endocrine and immune functions that plays
important roles in the physiological and pathological processes of the body. However, with …

[HTML][HTML] Bidirectional crosstalk between the peripheral nervous system and lymphoid tissues/organs

A Boahen, D Hu, MJ Adams, PK Nicholls… - Frontiers in …, 2023 - frontiersin.org
The central nervous system (CNS) influences the immune system generally by regulating
the systemic concentration of humoral substances (eg, cortisol and epinephrine), whereas …

[HTML][HTML] OVOL2 sustains postnatal thymic epithelial cell identity

X Zhong, N Peddada, J Wang, JJ Moresco… - Nature …, 2023 - nature.com
Distinct pathways and molecules may support embryonic versus postnatal thymic epithelial
cell (TEC) development and maintenance. Here, we identify a mechanism by which TEC …

[HTML][HTML] Thymus-derived hormonal and cellular control of cancer

W Savino, A Lepletier - Frontiers in Endocrinology, 2023 - frontiersin.org
The thymus gland is a central lymphoid organ in which developing T cell precursors, known
as thymocytes, undergo differentiation into distinct type of mature T cells, ultimately migrating …

Deciphering the M-cell niche: insights from mouse models on how microfold cells “know” where they are needed

D Del Castillo, DD Lo - Frontiers in Immunology, 2024 - frontiersin.org
Known for their distinct antigen-sampling abilities, microfold cells, or M cells, have been well
characterized in the gut and other mucosa including the lungs and nasal-associated …

[HTML][HTML] Immunological and virological triggers of type 1 diabetes: insights and implications

JRN Lemos, K Hirani, M von Herrath - Frontiers in Immunology, 2024 - frontiersin.org
Type 1 diabetes (T1D) is caused by an autoimmune process which culminates in the
destruction of insulin-producing beta cells in the pancreas. It is widely believed that a …

[HTML][HTML] Thymosin β4 Regulates the Differentiation of Thymocytes by Controlling the Cytoskeletal Rearrangement and Mitochondrial Transfer of Thymus Epithelial …

Y Ying, N Tao, F Zhang, X Wen, M Zhou… - International Journal of …, 2024 - mdpi.com
The thymus is one of the most crucial immunological organs, undergoing visible age-related
shrinkage. Thymic epithelial cells (TECs) play a vital role in maintaining the normal function …

[HTML][HTML] Whole-transcriptome profiling reveals potential biomarkers for the reversal of thymic epithelial cell senescence by umbilical cord mesenchymal stem cells

ZL Yang, C Tian, J He, H Pan, GP Ruan, J Zhao… - Aging (Albany …, 2024 - ncbi.nlm.nih.gov
Background: Reduced numbers and dysfunction of thymic epithelial cells (TECs) are
important factors of thymic degeneration. Previous studies have found that umbilical cord …

[HTML][HTML] Physiological and pathological roles of the thymus and value of thymectomy in myasthenia gravis: a narrative review

W Waheed, A Bacopulos, M Seyam, H Kooperkamp… - Mediastinum, 2024 - ncbi.nlm.nih.gov
Physiological and pathological roles of the thymus and value of thymectomy in myasthenia
gravis: a narrative review - PMC Back to Top Skip to main content NIH NLM Logo Access keys …

[HTML][HTML] T 淋巴细胞体外发育方法的研究进展

LI Yun, C Xin - Journal of Zhejiang University (Medical Sciences), 2022 - ncbi.nlm.nih.gov
Abstract T 淋巴细胞( 简称T 细胞) 在细胞过继免疫治疗( ACT) 中发挥重要作用, 利用T
细胞体外发育方法可获得来源稳定且获取简便的T 细胞, 相比从自体或同种异体组织分离得到T …