The comet assay as a tool for human biomonitoring studies: the ComNet project

A Collins, G Koppen, V Valdiglesias, M Dusinska… - … research/reviews in …, 2014 - Elsevier
The comet assay is widely used in human biomonitoring to measure DNA damage as a
marker of exposure to genotoxic agents or to investigate genoprotective effects. Studies …

The alkaline comet assay: towards validation in biomonitoring of DNA damaging exposures

P Møller - Basic & clinical pharmacology & toxicology, 2006 - Wiley Online Library
Generation of DNA damage is considered to be an important initial event in carcinogenesis.
The single cell gel electrophoresis (comet) assay is a technically simple and fast method that …

In vitro interactions between DMSA-coated maghemite nanoparticles and human fibroblasts: a physicochemical and cyto-genotoxical study

M Auffan, L Decome, J Rose, T Orsiere… - … science & technology, 2006 - ACS Publications
Although the current production of oxide nanoparticles may be modest, the wide range of
proposed applications and forecasted growth in production has raised questions about the …

Oxidative DNA damage in human peripheral leukocytes induced by massive aerobic exercise

K Tsai, TG Hsu, KM Hsu, H Cheng, TY Liu… - Free Radical Biology …, 2001 - Elsevier
Reactive oxygen species produced during vigorous exercise may permeate into cell nuclei
and induce oxidative DNA damage, but the supporting evidence is still lacking. By using a …

Measurement of DNA damage with the comet assay in high-prevalence diseases: current status and future directions

P Møller, H Stopper, AR Collins - Mutagenesis, 2020 - academic.oup.com
The comet assay is widely used in studies on genotoxicity testing, human biomonitoring and
clinical studies. The simple version of the assay detects a mixture of DNA strand breaks and …

Technical recommendations to perform the alkaline standard and enzyme-modified comet assay in human biomonitoring studies

A Azqueta, D Muruzabal, E Boutet-Robinet… - … /Genetic Toxicology and …, 2019 - Elsevier
The comet assay (single cell gel electrophoresis) is widely used as a biomonitoring tool to
assess DNA damage–strand breaks, as well as oxidised bases; it can also be adapted to …

Statistics of the Comet assay: a key to discriminate between genotoxic effects

P Duez, G Dehon, A Kumps, J Dubois - Mutagenesis, 2003 - academic.oup.com
The alkaline Comet assay is a widely used single cell gel electrophoresis technique for the
quantification of DNA strand breaks, crosslinks and alkali-labile sites induced by a series of …

Senescence of primary amniotic cells via oxidative DNA damage

R Menon, I Boldogh, R Urrabaz-Garza, J Polettini… - PloS one, 2013 - journals.plos.org
Objective Oxidative stress is a postulated etiology of spontaneous preterm birth (PTB) and
preterm prelabor rupture of the membranes (pPROM); however, the precise mechanistic role …

Genotoxicity of acrylamide in human hepatoma G2 (HepG2) cells

L Jiang, J Cao, Y An, C Geng, S Qu, L Jiang, L Zhong - Toxicology in Vitro, 2007 - Elsevier
The recent finding that acrylamide (AA), a carcinogen in animal experiments and a probable
human carcinogen, is formed in foods during cooking raises human health concerns. The …

No effect of 600 grams fruit and vegetables per day on oxidative DNA damage and repair in healthy nonsmokers

P Møller, U Vogel, A Pedersen, LO Dragsted… - … Biomarkers & Prevention, 2003 - AACR
In several epidemiological studies, high intakes of fruits and vegetables have been
associated with a lower incidence of cancer. Theoretically, intake of antioxidants by …