Three great plague pandemics, resulting in nearly 200 million deaths in human history and
usage as a biowarfare agent, have made Yersinia pestis as one of the most virulent human …

Primary pneumonic plague is transmitted easily, progresses rapidly, and causes high
mortality, but the mechanisms by which Yersinia pestis overwhelms the lungs are largely …

Yersinia pestis (YP), the gram-negative plague bacterium, has shaped human history unlike
any other pathogen known to mankind. YP (transmitted by the bite of an infected flea) …

Yersinia pestis evolved from Y. pseudotuberculosis to become the causative agent of
bubonic and pneumonic plague. We identified a homolog of the Salmonella enterica serovar …

Disease progression of primary pneumonic plague is biphasic, consisting of a
preinflammatory and a proinflammatory phase. During the long preinflammatory phase …

Y ersinia pestis, the cause of the disease plague, forms biofilms to enhance flea‐to‐mammal
transmission. Biofilm formation is dependent on exopolysaccharide synthesis and is …

Yersinia pestis causes pneumonic plague, a disease characterized by inflammation,
necrosis and rapid bacterial growth which together cause acute lung congestion and …

Type three secretion systems (TTSSs) are virulence factors found in many pathogenic Gram-
negative species, including the family of pathogenic Yersinia spp. Y ersinia …

DNA microarrays are a powerful and promising approach to gain a detailed understanding
of the bacterial response and the molecular cross-talk that can occur as a consequence of …

Plague is characterized by its potentially explosive spread during human epidemics and
rodent epizootics. Recent research has suggested how this spread is likely to occur and …