1.1. Organization of Committee and Evidence Review (UPDATED) For new or updated text,
view the 2011 Focused Update and the 2011 Update on Dabigatran. Text supporting …

Atrial fibrillation (AF) is the most common sustained cardiac rhythm disturbance, increasing
in prevalence with age. AF is often associated with structural heart disease, although a …

Background Amiodarone is effective in maintaining sinus rhythm in atrial fibrillation but is
associated with potentially serious toxic effects. Dronedarone is a new antiarrhythmic agent …

Inadequacies in current therapies for atrial fibrillation have made new drug development
crucial. Conventional antiarrhythmic drugs increase the risk of ventricular proarrhythmia. In …

Atrial fibrillation (AF) is the most common sustained cardiac rhythm disturbance, increasing
in prevalence with age. AF is often associated with structural heart disease, although a …

Recent studies suggest that atrial fibrillation (AF) is maintained by fibrillatory conduction
emanating from a small number of high-frequency reentrant sources (rotors). Our goal was …

Studies in animal models have provided extremely important insights about atrial fibrillation
(AF). The classic mechanisms that still form the framework for our understanding of AF (focal …

Atrial fibrillation is the most common sustained cardiac arrhythmia, and contributes greatly to
cardiovascular morbidity and mortality. Many aspects of the management of atrial fibrillation …

Background: The hyperpolarization-activated cation current I f contributes significantly to
sinoatrial node pacemaker function and possibly to ectopic arrhythmogenesis. Little is …

Background—The development of atrium-selective antiarrhythmic agents is a current
strategy for inhibiting atrial fibrillation (AF). The present study investigated whether the …