The skin is the front line of defense against insult and injury and contains many epidermal
and immune elements that comprise the skin-associated lymphoid tissue (SALT). The …

Psoriasis is a prevalent, chronic inflammatory disease of the skin, mediated by crosstalk
between epidermal keratinocytes, dermal vascular cells, and immunocytes such as antigen …

Certain therapeutic microbes, including Bifidobacteria infantis (B. infantis) 35624 exert
beneficial immunoregulatory effects by mimicking commensal-immune interactions; …

Objectives To review the pathophysiology, co-morbidities, and therapeutic options for
psoriasis, psoriatic arthritis and rheumatoid arthritis in order to further understand the …

IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in
human immune-mediated diseases. Genome-wide association studies have shown that the …

Psoriasis is a common inflammatory skin disease of unknown etiology, for which there is no
cure. This heterogeneous, cutaneous, inflammatory disorder is clinically characterized by …

Background Tumor necrosis factor-α (TNF-α) inhibitors have been reported to induce new-
onset psoriasis. Objective To better define the demographic, clinical features, and treatment …

Tumor necrosis factor α (TNF-α)-targeted therapies have expanded the therapeutic options
for patients with inflammatory bowel disease (IBD), rheumatoid arthritis (RA), psoriasis, and …

The skin is the largest organ of the body. The establishment of immunological memory in the
skin is a crucial component of the adaptive immune response. Once naive T cells are …

Abstract Interleukin-15 (IL-15) is a member of the IL-2 family of cytokines, which use receptor
complexes containing the common gamma (γ c) chain for signaling. IL-15 plays important …