The potential impact of neuroimaging and translational research on the clinical management of lacunar stroke

S Rudilosso, A Rodríguez-Vázquez, X Urra… - International journal of …, 2022 - mdpi.com
Lacunar infarcts represent one of the most frequent subtypes of ischemic strokes and may
represent the first recognizable manifestation of a progressive disease of the small …

Targeting neutrophils in ischemic stroke: translational insights from experimental studies

GC Jickling, DZ Liu, BP Ander… - Journal of Cerebral …, 2015 - journals.sagepub.com
Neutrophils have key roles in ischemic brain injury, thrombosis, and atherosclerosis. As
such, neutrophils are of great interest as targets to treat and prevent ischemic stroke. After …

Cytokine storm induced by SARS-CoV-2 infection: The spectrum of its neurological manifestations

P Thepmankorn, J Bach, A Lasfar, X Zhao, S Souayah… - Cytokine, 2021 - Elsevier
The new coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), can trigger a hyperinflammatory state characterized …

Caspase-1 inhibitor exerts brain-protective effects against sepsis-associated encephalopathy and cognitive impairments in a mouse model of sepsis

X Xu, L Liu, Y Wang, C Wang, Q Zheng, Q Liu… - Brain, behavior, and …, 2019 - Elsevier
Sepsis-associated encephalopathy (SAE) manifested clinically in acute and long-term
cognitive impairments and associated with increased morbidity and mortality worldwide. The …

Systemic inflammation as a therapeutic target in acute ischemic stroke

T Dziedzic - Expert review of neurotherapeutics, 2015 - Taylor & Francis
Acute systemic inflammatory reaction superimposed on chronic low-grade inflammation
accompanies acute ischemic stroke. Elevated blood levels of systemic inflammatory markers …

Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders

H Anisman, Z Merali, S Hayley - Progress in neurobiology, 2008 - Elsevier
Given the array of biological changes induced by stressors, it is not surprising that these
experiences may provoke a variety of illnesses. Among others things, stressors promote …

The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines

G Spalletta, P Bossu, A Ciaramella, P Bria… - Molecular …, 2006 - nature.com
Although poststroke depression is unlikely to represent a single disorder and numerous
etiologies for different kinds of poststroke depression will likely emerge as the result of future …

Perspective of SGLT2 inhibition in treatment of conditions connected to neuronal loss: focus on Alzheimer's disease and ischemia-related brain injury

M Wiciński, E Wódkiewicz, K Górski, M Walczak… - Pharmaceuticals, 2020 - mdpi.com
Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are oral anti-hyperglycemic agents
approved for the treatment of type 2 diabetes mellitus. Some reports suggest their presence …

Inflammatory molecules might become both biomarkers and therapeutic targets for stroke management

L Ramiro, A Simats… - Therapeutic …, 2018 - journals.sagepub.com
Stroke is the fifth leading cause of death and the most frequent cause of disability worldwide.
Currently, stroke diagnosis is based on neuroimaging; therefore, the lack of a rapid tool to …

Inflammation in ischemic stroke subtypes

A Tuttolomondo, D Di Raimondo… - Current …, 2012 - ingentaconnect.com
Determining the cause of stroke does influence choices for management. categorization of
subtypes of ischemic stroke has had considerable study, but definitions are hard to formulate …