Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as
promising candidate targets for cancer treatment. These proteins complexed with cyclins …

Abstract The Raf/MEK/ERK (MAPK) signal transduction cascade is a vital mediator of a
number of cellular fates including growth, proliferation and survival, among others. The focus …

Incubation of endothelial cells in vitro with high concentrations of glucose activates protein
kinase C (PKC) and increases nitric oxide synthase (NOS III) gene expression as well as …

Staurosporine is the most potent inhibitor of protein kinase C (PKC) described in the
literature with a half-maximal inhibitory concentration (IC50) of 10 nM. Nevertheless, this …

Indolocarbazoles have been identified as novel inhibitors of protein kinase C (PKC), with Gö
6976 as one of its most potent and selective representatives. Recombinant PKC isozymes …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Rottlerin, a compound from Mallotus philippinensis, is shown to inhibit protein kinases with
some specificity for PKC. To some extent, the novel inhibitor is able to differentiate between …

Leukemic cells from 30% of patients with acute myeloid leukemia (AML) have an activating
mutation in the FLT3 (fms-like tyrosine kinase) gene, which represents a target for drug …

The intracellular signaling involved in the mechanism of action of zonula occludens toxin
(ZOT) was studied using several in vitro and ex vivo models. ZOT showed a selective effect …

Background: Arrest of the cell cycle in G2 phase following DNA damage helps protect cell
viability by allowing time for DNA repair before entry into mitosis (M phase). Abrogation of …