The platelet-derived growth factor (PDGF) receptor is a member of the transmembrane
growth factor receptor protein family with intrinsic protein-tyrosine kinase activity. We …

The maturing mutational landscape of cancer genomes, the development and application of
clinical interventions and evolving insights into tumour-associated functions reveal …

Striking homology between signaling molecules in zebrafish and humans suggests that
compounds known to inhibit human kinases may enable a chemical genetic approach to …

A series of potent, selective inhibitors of protein kinase C has been derived from the
structural lead provided by the microbial broth products, staurosporine and K252a. Our …

The process of cervical ripening has been likened to an inflammatory reaction associated
with the catabolism of cervical extracellular matrix by enzymes released from infiltrating …

It is well established that oxidative stress is enhanced in diabetes. However, the major in
vivo source of oxidative stress is not clear. Here we show that vascular NAD (P) H oxidase …

Plant cells have an acute sense for pathogen-derived chemical stimuli, so-called elicitors,
which induce the plant's defense response. To investigate the molecular basis of …

The phosphorylation and localization of the membrane-linking protein moesin was analyzed
during early activation of platelets with thrombin. Activated platelets elaborate filopodia and …

Cell division (mitosis) is one of the basic requirements for multicellular oranisms. The
capability of a cell to replicate enables a complex assembly to be created. Faulty regulation …

Systemic mastocytosis (SM) is a heterogeneous disease, vast majority of these patients
have a gain of function mutation in the gene encoding the tyrosine kinase KIT (KITD816V). A …