A hypothetical mode ofinhibition of protein kinase C (PKC) by the natural product
staurosporine has been used as a basis for thedesign of substituted bisindolylmaleimides …

We have identified 20-mer phosphorothioate oligodeoxynucleotides which potently (IC50
values of 100-200 nM) and specifically inhibit protein kinase C (PKC)-alpha mRNA and …

Phosphorylation of the expressed NS5A protein of hepatitis C virus (HCV), a member of the
Hepacivirus genus of the family Flaviviridae, has been demonstrated in mammalian cells …

CGP 41251 was originally identified as an inhibitor of protein kinase C (PKC), inhibiting
mainly the conventional PKC subtypes, and subsequently shown to inhibit the vascular …

Protein kinase C (PKC) comprises a family of isozymes (α, βI, βII, γ δ, ε, θ, & eegr;, λ/ι
[mouse/human], and ζ) which are involved in signal transduction from membrane receptors …

Background: Numerous analogs of the antitumor agents epothilones A and B have been
synthesized in search of better pharmacological profiles. Insights into the structure–activity …

Background: Staurosporine inhibits most protein kinases at low nanomolar concentrations.
As most tyrosine kinases, along with many serine/threonine kinases, are either proto …

The most common cause of new blindness in young patients is retinal neovascularization,
and in the elderly is choroidal neovascularization. Therefore, there has been a great deal of …

The role of PKC isoforms in signal transduction pathways involved in regulation of the cell
cycle, apoptosis, angiogenesis, differentiation, invasiveness, senescence and drug efflux …

Many investigators have embarked upon the search for novel cellular targets for the
treatment of cancer. A popular therapeutic strategy is to intervene with the components of …