Abstract Learning Objectives After completing this course, the reader should be able to:
Understand protein kinase C (PKC) in signal transduction pathways. Understand protein …

Protein kinases C (PKCs) are a family of serine/threonine kinases which are involved in
tumor formation and progression. Although PKC over-expression has been shown to …

The mechanism by which thrombin induces neurite retraction was studied in NB2a mouse
neuroblastoma cells. The rapid effect of thrombin (completed within minutes) appears to …

PURPOSE: To increase the therapeutic efficacy of ionizing radiation or to reduce radiation-
mediated side effects, diverse research centers for translational radiation oncology have …

Protein Kinase C (PKC) is a family of serine–threonine kinases found in most cell types
whose activity has a strong influence on a wide variety of signal transduction events …

Using a pharmacophore model for ATP-competitive inhibitors interacting with the active site
of the EGFR protein tyrosine kinase together with published X-ray crystal data of quercetin …

The understanding of cellular communication pathways in molecular detail is an important
goal of bioorganic research. The synthesis of analogues of active substances (eg 1) to study …

The receptor tyrosine kinase FLT3 is a promising molecular therapeutic target in acute
myeloid leukemia (AML). Activating mutations of FLT3 are present in approximately one …

In the past decade it has become apparent that many diseases result from aberrations in
signaling pathways. These include proliferative diseases such as cancers, atherosclerosis …

The effect of phenylpyrroles on glycerol synthesis in Neurospora crassa has been
investigated and compared with the mode of action of vinclozolin (a dicarboximide). The …