Fms-like tyrosine kinase 3 (FLT3) receptor mutations as internal tandem duplication (ITD) or
within the kinase domain are detected in up to 35% of patients with acute myeloid leukemia …

Four monoclonal antibodies (MAbs) specific for the extracellular domain of the human erbB-
2/HER2 protein (FRP5, FSP16, FWP51 and FSP77) have been isolated (Harwerth et al., J …

Abstract Fms-related-tyrosine kinase 3 (FLT3) mutations occur in approximately a third of
acute myeloid leukemia (AML) patients and confer an adverse prognosis. Numerous studies …

The toxicity on three human tumor cell lines (A431, HeLa and MCF7) of five
phenanthroperylenequinones (hypericin and derivatives) and two perylenequinones …

6 indolo [2, 3-a] carbazole (1) 1H-indolo [2, 3-a] pyrrolo [3, 4-c] carbazole (2) Since the
synthetic approaches to indolo [2, 3-a] carbazoles were reviewed in volume 1 of this series …

UCN-01 (7-hydroxystaurosporine) is a protein kinase inhibitor which is under development
as an anti-cancer agent in the USA and Japan. Although UCN-01 was originally isolated …

Abstract PREVIOUS WORK HAS demonstrated the importance of the Protein Kinase C
(PKC) signal transduction system in regulating the growth rate of malignant gliomas in vitro …

Permanent cell culture lines derived from human breast cancer tissue are important
experimental models in the study of human breast cancer cell proliferation. In the present …

Evidence has emerged over the past decade to suggest thnt protein kinnse C (PM3 is a
widespread family of kirrnses responsible for mnny diverse nrzd crztical cellular functions …

Activation of transcription factor NF-κB is regulated by phosphorylation and subsequent
degradation of its inhibitory subunit IκB. The signal-induced phosphorylation of IκB involves …